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MEP1A

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MEP1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMEP1A, PPHA, meprin A subunit alpha
External IDsOMIM: 600388; MGI: 96963; HomoloGene: 31323; GeneCards: MEP1A; OMA:MEP1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005588

NM_008585

RefSeq (protein)

NP_005579

NP_032611

Location (UCSC)Chr 6: 46.79 – 46.84 MbChr 17: 43.79 – 43.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A enzyme that in humans is encoded by the MEP1A gene.[5][6] The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice.[7]

Function

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The meprin alpha subunit product of the MEP1A gene is processed in the endoplasmic reticulum during intracellular transport, and is secreted as homomeric meprin A. Meprin alpha subunits may self-associate, and once secreted, form very large multimers, with a molecular mass of over 1 million daltons. In cells concurrently expressing MEP1B, the meprin alpha and meprin beta subunits form disulfide dimers that interact to form membrane bound heterotetrameric meprin A.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112818Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023914Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bond JS, Rojas K, Overhauser J, Zoghbi HY, Jiang W (Jul 1995). "The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively". Genomics. 25 (1): 300–3. doi:10.1016/0888-7543(95)80142-9. PMID 7774936.
  6. ^ "Entrez Gene: MEP1A meprin A, alpha (PABA peptide hydrolase)".
  7. ^ Banerjee S, Oneda B, Yap LM, Jewell DP, Matters GL, Fitzpatrick LR, Seibold F, Sterchi EE, Ahmad T, Lottaz D, Bond JS (May 2009). "MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease". Mucosal Immunol. 2 (3): 220–31. doi:10.1038/mi.2009.3. PMC 2670347. PMID 19262505.

Further reading

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