2,4-dichlorobenzoyl-CoA reductase
Appearance
2,4-dichlorobenzoyl-CoA reductase | |||||||||
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Identifiers | |||||||||
EC no. | 1.3.1.63 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2,4-dichlorobenzoyl-CoA reductase (EC 1.3.1.63) is an enzyme that catalyzes the chemical reaction
- 4-chlorobenzoyl-CoA + NADP+ + HCl 2,4-dichlorobenzoyl-CoA + NADPH + H+
The 3 substrates of this enzyme are 4-chlorobenzoyl-CoA, NADP+, and HCl, whereas its 3 products are 2,4-dichlorobenzoyl-CoA, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating). This enzyme participates in 2,4-dichlorobenzoate degradation.
References
[edit]- Romanov V, Hausinger RP (1996). "NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform bacterium strainNTB-1 via 2,4-dichlorobenzoyl coenzyme A". J. Bacteriol. 178 (9): 2656–61. PMC 177992. PMID 8626335.