SRD5A2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SRD5A2
Identifiers
Aliases SRD5A2, entrez:6716
External IDs OMIM: 607306 MGI: 2150380 HomoloGene: 37292 GeneCards: SRD5A2
Targeted by Drug
finasteride[1]
RNA expression pattern
PBB GE SRD5A2 206938 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000348

NM_053188

RefSeq (protein)

NP_000339

NP_444418.1
NP_444418

Location (UCSC) Chr 2: 31.52 – 31.58 Mb Chr 17: 74.02 – 74.05 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

3-oxo-5-alpha-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene.[4][5]

Steroid 5-alpha reductase catalyzes the conversion of the male sex hormone testosterone into the more potent androgen, dihydrotestosterone.

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).[5]

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.