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Namandjé Bumpus

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Namandjé Bumpus
Born (1981-02-07) February 7, 1981 (age 43)[citation needed]
Philadelphia, Pennsylvania, U.S.[citation needed]
Alma materOccidental College (B.A. 2003)[2]
University of Michigan (Ph.D. 2007)[3][4]
Known forresearch on cytochrome P450s, antiviral drug metabolism
AwardsPresidential Early Career Award for Scientists and Engineers John J. Abel Award
Scientific career
Fieldspharmacology; drug metabolism; toxicology; pharmacogenetics; pharmacokinetics
InstitutionsJohns Hopkins University School of Medicine
Doctoral advisorPaul F. Hollenberg[1]

Namandjé N. Bumpus is an American pharmacologist and the Chief Scientist of the Food and Drug Administration.[3] She was previously director of the department of pharmacology and molecular sciences at Johns Hopkins University School of Medicine, where she holds the E.K. Marshall and Thomas H. Maren professorship in pharmacology.[5][3] Bumpus is known for her research on the metabolism of antiviral drugs used to treat HIV-1 and how genetic variations in drug-processing enzymes may impact these drugs' efficacy.[6] Bumpus received a Presidential Early Career Award for Scientists and Engineers in 2016.[7]

Early life and education

Namandjé Bumpus was born in Philadelphia and raised in western Massachusetts.[8] She became interested in chemistry at a young age, even writing to the American Chemical Society while still in elementary school to ask about the kind of careers chemists can have.[9]

She earned a B.A. in Biology from Occidental College, in Los Angeles, California, in 2003.[2] At Occidental, she was introduced to research experiences in ecology, then she ventured into pharmacology through Charles Ross Summer Research Fellowship at the University of Michigan, during which she was mentored by Dr. Richard R. Neubig.[10] She enjoyed the experience so much that she decided to return to the University of Michigan after graduating from Occidental College in order to pursue a PhD in pharmacology.[10]

She earned her Ph.D. in pharmacology from the University of Michigan Medical School in 2007.[2][11] Her thesis research, and much of her later work, examined how drugs are processed by cytochrome P450 enzymes, (CYPs) a family of heme-containing monooxygenases, that often help make drugs more soluble, aiding with drug clearance.[12] Bumpus performed her thesis research in the laboratory of Dr. Paul F. Hollenberg, investigating how a naturally occurring mutation in CYP2B6 affects its ability to be inactivated by compounds known the inactivate the wild-type CYP2B6.[13] She also looked into how naturally-occurring variants could impact how patients cleared the antidepressant Bupropion, and the antiviral Efavirenz.[8]

After graduating, she accepted a postdoctoral fellowship at the Scripps Research Institute in La Jolla, California, where she worked under the guidance of Dr. Eric F. Johnson to study the regulation of CYP4A and CYP4F genes in mice.[13] She studied what cellular pathways regulated fatty acid metabolism and how stress pathways influence the CYPs that metabolize lipids.[8]

Career

Academic career

Bumpus is a Professor of Medicine in the clinical pharmacology division of Johns Hopkins University School of Medicine, with a secondary appointment in the Department of Pharmacology and Molecular Sciences.[2] She started her own laboratory at Johns Hopkins School of Medicine in 2010 as an Assistant Professor of Medicine and Pharmacology, was promoted to Associate Professor in February 2015,[11] and received Professorship in 2020.[5]

In July 2018, she was named as Associate Dean for Basic Research at Johns Hopkins University School of Medicine.[14] In this role, she serves as an advocate and liaison for basic science researchers working in clinical departments to help facilitate the combination of “basic research” which seeks to answer fundamental scientific questions and “translational research” that seeks to put those findings to use, for example in a clinical setting.[14]

She became Hopkins’ inaugural associate dean of institutional and student equity in 2015 and instituted mentoring programs to expand access to resources and opportunities.[15] After holding that role for two years, in July 2017 she transitioned into a role as senior consulting strategist for Academic and Research Diversity, working with the chief diversity officer to develop and implement diversity and inclusion programs across Johns Hopkins School of Medicine.[16]

In 2020, she was named director of the department of pharmacology and molecular sciences at Johns Hopkins University School of Medicine, becoming the first African-American director of a basic science department, and the first Black woman to chair any department, at Johns Hopkins University School of Medicine.[17][18][5]

Bumpus has served numerous roles outside of Johns Hopkins. She chairs the National Institute of Health (NIH)'s Xenobiotic and Nutrient Disposition and Action study section[2] and serves as a science commissioner and member of Washington, D.C.’s Science Advisory Board.[14] She is an associate editor of the journal Drug Metabolism and Disposition.[2]

She has been strongly involved with the American Society for Pharmacology and Experimental Therapeutics (ASPET), where she served as secretary and treasurer.[2] She was elected Councilor of ASPET in 2019 and began her term in July 2019.[19]

Government career

On June 30, 2022, Bumpus became the Chief Scientist at the Food and Drug Administration.[20][3]

Research

A major thread of Bumpus' research is determining how antiviral drugs used to treat HIV-1 are metabolized and how genetic variations in drug-processing enzymes may impact these drugs' efficacy.[6]

One antiviral commonly used to treat and prevent HIV is tenofovir (Viread). Tenofovir is a nucleotide analog reverse transcriptase inhibitor that prevents the HIV virus from replicating.[21] Tenofovir is given in an inactive form – it has to be phosphorylated twice to become active, and this phosphorylation is carried out in two steps by separate kinases. Bumpus and her team identified which kinases do this and found that the enzymes responsible varied by cell type, so administration route (e.g. orally or topically) could affect how effectively the drug is processed.[22] They also sequenced the genes of these kinases from different patients and found that some people have genetic variants in the kinases that may affect how effectively the drug is processed.[22] Tenofovir can be given prophylactically, and Bumpus collaborated with researchers from around the world in a study of the use of tenofovir for HIV pre-exposure prophylaxis (PrEP) to prevent HIV infection in heterosexual men and women.[23]

Bumpus has also researched nonnucleoside reverse transcriptase inhibitors. Her lab was the first to publish the P450-catalyzed phase 1 and phase 2 metabolic pathways of two nonnucleoside reverse transcriptase inhibitors, rilpivirine and etravirine and was first to characterize the metabolism of the nonnucleoside reverse transcriptase inhibitor dapivirine.[13] She also studies antivirals that work through mechanisms other than reverse transcriptase inhibition such as the HIV entry inhibitor maraviroc; she found that genetic variants of CYP3A genes could impact its clearance.[13]

Bumpus' lab also found that cytochrome P450 enzymes convert the anti-epileptic valproic acid into byproducts (metabolites) that activate AMPK; they showed that this could reverse the obesity-related problems of fatty liver disease and high blood sugar in mouse models.[24]

Personal life

Outside of the lab, Bumpus enjoys sports including running and playing basketball.[9] She is also strongly involved in community service in Washington, D.C.[9] She volunteers at Food & Friends, which provides meals to people with life-challenging illnesses including HIV and worked with friends to organize transportation to farmers markets for people living in food deserts.[9]

Honors and awards

Bumpus has received numerous recognitions from the United States government for her work. In 2016, President Obama awarded her a Presidential Early Career Award for Scientists and Engineers, "the highest honor bestowed by the United States Government on science and engineering professionals in the early stages of their independent research careers".[7] She delivered the National Institute of General Medical Sciences (NIGMS) Director's Early-Career Investigator Lecture in 2017,[14] and was the Congressional Biomedical Research Caucus's invited speaker in March 2018, lecturing about informing consumers about drug metabolism.[25] Bumpus became a fellow of the American Association for the Advancement of Science, in its Section on Pharmaceutical Sciences, in 2021.[26][3] In 2022, she was elected to the National Academy of Medicine.[27][3]

Additional awards she has received include:

References

  1. ^ "Academic Family Tree of Namandjé N. Bumpus". Retrieved May 27, 2020.
  2. ^ a b c d e f g h "Namandje N. Bumpus, Ph.D." www.hopkinsmedicine.org. Retrieved 2019-04-14.
  3. ^ a b c d e f "Dr. Namandjé N. Bumpus, Chief Scientist - Office of the Chief Scientist". Food and Drug Administration. Retrieved September 20, 2022.
  4. ^ "Bumpus's official website". Johns Hopkins Medicine. Retrieved June 4, 2019.
  5. ^ a b c "Bumpus promoted; Regev to join Rohe board; remembering Peter Lengyel". www.asbmb.org. Retrieved 2020-05-27.
  6. ^ a b "2 Johns Hopkins Researchers Win Presidential Early Career Awards – 02/22/2016". www.hopkinsmedicine.org. Retrieved 2019-04-14.
  7. ^ a b "President Obama Honors Extraordinary Early-Career Scientists". whitehouse.gov. 2016-02-18. Retrieved 2019-04-14.
  8. ^ a b c Dunbar, Anwar (2016-06-06). "Black History Month: An interview with Dr. Namandje Bumpus". The Edvocate. Retrieved 2019-04-14.
  9. ^ a b c d Kolf, Catherine. "Namandje Bumpus on Chemistry, Sports and Community Service". www.hopkinsmedicine.org. Retrieved 2019-04-14.
  10. ^ a b "Namandje Bumpus, Ph.D." www.asbmb.org. Archived from the original on 2017-09-21. Retrieved 2019-04-14.
  11. ^ a b "Congrats to Dr. Namandjé N. Bumpus | Pharmacology | Michigan Medicine | University of Michigan". medicine.umich.edu. 2015-02-09. Retrieved 2019-04-14.
  12. ^ "PDB101: Molecule of the Month: Cytochrome p450". RCSB: PDB-101. Retrieved 2019-04-14.
  13. ^ a b c d "Namandje Bumpus, Ph.D." PhRMA Foundation. Retrieved 2019-04-14.
  14. ^ a b c d Rosen, Antony (July 20, 2018). "ICTR Researcher Namandjé Bumpus Named Associate Dean for Basic Research | ICTR". Retrieved 2019-04-14.
  15. ^ Staff, Daily Record (2017-11-30). "Dr. Namandje N. Bumpus". Maryland Daily Record. Retrieved 2019-04-14.
  16. ^ "ICTR in the News: Dr. Namandjé Bumpus to Transition to New Role Partnering with Chief Diversity Officer of Johns Hopkins Medicine | ICTR". Retrieved 2019-04-14.
  17. ^ says, Tammy L. Cooper (2020-05-15). "Three African American Women Faculty Taking on New Assignments". The Journal of Blacks in Higher Education. Retrieved 2020-05-27.
  18. ^ Booker, Squire [@@BookerMan_PSU] (18 May 2020). "...She is the first Black woman to ever chair a department @HopkinsMedicine!!!" (Tweet) – via Twitter.
  19. ^ "ASPET | 2019 ASPET Election Results". www.aspet.org. Retrieved 2019-04-14.
  20. ^ Califf, Robert [@DrCaliff_FDA] (June 30, 2022). "Job Announcement" (Tweet). Retrieved July 1, 2022 – via Twitter.
  21. ^ Akanbi, Maxwell O; Scarci, Kimberly; Taiwo, Babafemi; Murphy, Robert L (January 2012). "Combination Nucleoside/ Nucleotide Reverse Transcriptase Inhibitors". Expert Opinion on Pharmacotherapy. 13 (1): 65–79. doi:10.1517/14656566.2012.642865. ISSN 1465-6566. PMC 3397780. PMID 22149368.
  22. ^ a b "New Evidence That Genetic Differences May Help Explain Inconsistent Effectiveness Of Anti-HIV Drug". www.hopkinsmedicine.org. July 9, 2015. Retrieved 2019-04-14.
  23. ^ Baeten, Jared M.; Donnell, Deborah; Ndase, Patrick; Mugo, Nelly R.; Campbell, James D.; Wangisi, Jonathan; Tappero, Jordan W.; Bukusi, Elizabeth A.; Cohen, Craig R. (2012-08-01). "Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women". New England Journal of Medicine. 367 (5): 399–410. doi:10.1056/nejmoa1108524. PMC 3770474. PMID 22784037.
  24. ^ "Obesity-Induced Fatty Liver Disease Reversed In Mice". www.hopkinsmedicine.org. January 29, 2014. Retrieved 2019-04-14.
  25. ^ Bennett, Kelsey (2018-04-05). "Bumpus Speaks in Front of Congress". Medicine Matters. Retrieved 2019-04-14.
  26. ^ "Seven Johns Hopkins researchers named AAAS fellows". The Hub. Johns Hopkins University. Jan 26, 2022. Retrieved March 16, 2023.
  27. ^ "ASPET President-Elect Namandjé N. Bumpus, PhD Elected to the National Academy of Medicine". American Society for Pharmacology and Experimental Therapeutics (ASPET). October 18, 2022. Retrieved March 16, 2023.
  28. ^ a b "Alumni Awards and Honors | Pharmacology | Michigan Medicine | University of Michigan". medicine.umich.edu. 2014-10-28. Retrieved 2019-04-14.
  29. ^ "North American Region Award Winners Selected – International Society for the Study of Xenobiotics". www.issx.org. Retrieved 2019-04-14.
  30. ^ Staff, Daily Record (2017-10-10). "The Daily Record announces 2017 Leading Women honorees". Maryland Daily Record. Retrieved 2019-04-14.
  31. ^ "ASPET | 2019 Award Winners". www.aspet.org. Retrieved 2019-04-14.
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