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Metallothionein 1A

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MT1A

Identifiers

MT1A, MT1, MT1S, MTC, Metallothionein 1A, MT-1A, MT-IA

External IDs

OMIM: 156350; GeneCards: MT1A; OMA:MT1A - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16q13	Start	56,638,666 bp^[1]
Band	16q13	End	56,640,087 bp^[1]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

synovial membrane

middle frontal gyrus

epithelium of bronchus

metanephric glomerulus

spinal ganglia

thalamus

trachea

paraflocculus of cerebellum

frontal pole

vastus lateralis muscle

n/a

More reference expression data

n/a

Gene ontology
Molecular function	zinc ion binding protein binding metal ion binding
Cellular component	cytoplasm perinuclear region of cytoplasm cytosol nucleus
Biological process	response to metal ion negative regulation of growth cellular response to cadmium ion cellular response to zinc ion cellular zinc ion homeostasis detoxification of copper ion cellular response to copper ion
Sources:Amigo / QuickGO

Species

Human

Mouse


4489


n/a


ENSG00000205362


n/a


P04731


n/a

RefSeq (mRNA)


NM_005946


n/a

RefSeq (protein)


NP_005937


n/a

Location (UCSC)

Chr 16: 56.64 – 56.64 Mb

n/a

PubMed search

^[2]

n/a

View/Edit Human

Metallothionein-1A is a protein that in humans is encoded by the MT1A gene.^[3]^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205362 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proceedings of the National Academy of Sciences of the United States of America. 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi:10.1073/pnas.81.17.5494. PMC 391732. PMID 6089206.
^ Richards RI, Heguy A, Karin M (Jun 1984). "Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids". Cell. 37 (1): 263–72. doi:10.1016/0092-8674(84)90322-2. PMID 6327055.
^ "Entrez Gene: MT1A metallothionein 1A".

Further reading

Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, et al. (2007). "Metallothionein: an overview". World Journal of Gastroenterology. 13 (7): 993–6. doi:10.3748/wjg.v13.i7.993. PMC 4146885. PMID 17373731.
Sutherland GR, Baker E, Callen DF, et al. (1990). "The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia". Genomics. 6 (1): 144–8. doi:10.1016/0888-7543(90)90459-8. PMID 2303255.
Grider A, Bailey LB, Cousins RJ (1990). "Erythrocyte metallothionein as an index of zinc status in humans". Proceedings of the National Academy of Sciences of the United States of America. 87 (4): 1259–62. Bibcode:1990PNAS...87.1259G. doi:10.1073/pnas.87.4.1259. PMC 53453. PMID 2304897.
Le Beau MM, Diaz MO, Karin M, Rowley JD (1985). "Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia". Nature. 313 (6004): 709–11. Bibcode:1985Natur.313..709L. doi:10.1038/313709a0. PMID 3856101. S2CID 4321473.
Hunziker PE, Kägi JH (1985). "Isolation and characterization of six human hepatic isometallothioneins". Biochemical Journal. 231 (2): 375–82. doi:10.1042/bj2310375. PMC 1152756. PMID 4062903.
Armitage IM, Otvos JD, Briggs RW, Boulanger Y (1983). "Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR". Federation Proceedings. 41 (13): 2974–80. PMID 7140998.
Akintola DF, Sampson B, Fleck A (1995). "Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine". The Journal of Laboratory and Clinical Medicine. 126 (2): 119–27. PMID 7543551.
Davis SR, McMahon RJ, Cousins RJ (1998). "Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression". Journal of Nutrition. 128 (5): 825–31. doi:10.1093/jn/128.5.825. PMID 9566988.
Simpkins C, Lloyd T, Li S, Balderman S (1998). "Metallothionein-induced increase in mitochondrial inner membrane permeability". Journal of Surgical Research. 75 (1): 30–4. doi:10.1006/jsre.1997.5241. PMID 9614853.
Lau JC, Cherian MG (1999). "Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice". Biochemistry and Cell Biology. 76 (4): 615–23. doi:10.1139/bcb-76-4-615. PMID 10099782.
Levadoux M, Mahon C, Beattie JH, et al. (2000). "Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton". Journal of Biological Chemistry. 274 (49): 34961–6. doi:10.1074/jbc.274.49.34961. PMID 10574972.
Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer". The Prostate. 43 (2): 125–35. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528. S2CID 8768274.
Campagne MV, Thibodeaux H, van Bruggen N, et al. (2000). "Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion". The Journal of Neuroscience. 20 (14): 5200–7. doi:10.1523/JNEUROSCI.20-14-05200.2000. PMC 6772313. PMID 10884303.
Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood". European Journal of Biochemistry. 268 (3): 849–56. doi:10.1046/j.1432-1327.2001.01947.x. PMID 11168427.
Levadoux-Martin M, Hesketh JE, Beattie JH, Wallace HM (2001). "Influence of metallothionein-1 localization on its function". Biochemical Journal. 355 (Pt 2): 473–9. doi:10.1042/0264-6021:3550473. PMC 1221760. PMID 11284736.
Richarz AN, Brätter P (2002). "Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins". Analytical and Bioanalytical Chemistry. 372 (3): 412–7. doi:10.1007/s00216-001-1187-5. PMID 11939525. S2CID 21611530.
Minami T, Kubo K, Ichida S (2003). "Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH". Journal of Chromatography B. 779 (2): 211–9. doi:10.1016/S1570-0232(02)00375-6. PMID 12361735.

PDB gallery

1mhu: THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
1mrb: THREE-DIMENSIONAL STRUCTURE OF RABBIT LIVER CD7 METALLOTHIONEIN-2A IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE
2mhu: THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

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