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Clonally transmissible cancer

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A transmissible cancer is a cancer cell or cluster of cancer cells that can be transferred between individuals without the involvement of an infectious agent, such as an oncovirus.[1][2] The evolution of transmissible cancer has occurred naturally in other animal species, but human cancer transmission is rare.[2]

Humans

In humans, a significant fraction of Kaposi's sarcoma occurring after transplantation may be due to tumorous outgrowth of donor cells.[3] Although Kaposi's sarcoma is caused by a virus (Kaposi's sarcoma-associated herpesvirus), in these cases, it appears likely that transmission of virus-infected tumor cells—rather than the free virus—caused tumors in the transplant recipients.[2]

In 2007, four people (three women and one man) received different organ transplants (liver, both lungs and kidneys) from a 53-year-old woman who had recently died from intracranial bleeding. Before transplantation, the organ donor was deemed to have no signs of cancer upon medical examination. Later, the organ recipients developed metastatic breast cancer from the organs and three of them died from the cancer between 2009–2017.[4]

In 2014, a case of parasite-to-host cancer transmission occurred in a 41-year-old man in Colombia with a compromised immune system due to HIV. The man's tumor cells were shown to have originated from the dwarf tapeworm, Hymenolepis nana.[5] In the 1990s, an undifferentiated pleomorphic sarcoma was transmitted from a 32-year-old patient to his 53-year-old surgeon when he injured his hand during an operation. Within five months, a tumor had developed on the hand of the surgeon and was subsequently excised. Histologic examinations of the tumor tissues from the patient and surgeon showed that both were morphologically identical.[6] In 1986, a 19-year-old laboratory worker mistakenly punctured her hand with a needle previously used to extract human colonic cancer cells. No injection of the substance occurred, and the worker suffered a small puncture wound with bleeding. Within 19 days, she had developed a small cancerous nodule on her hand. The tumor was removed soon after, and has since shown no sign of reoccurrence.[7]

Other animals

Contagious cancers are known to occur in dogs, Tasmanian devils, Syrian hamsters, and some marine bivalves including soft-shell clams. These cancers have a relatively stable genome as they are transmitted.[8] Recent studies have tested whether other highly prevalent wildlife cancers, such as urogenital carcinomas in Californian sea lions, could also be contagious but so far there is no evidence for this.[9]

Clonally transmissible cancer, caused by a clone of malignant cells rather than a virus,[10] is an extremely rare disease modality,[11] with few transmissible cancers being known.[1] The evolution of transmissible cancer is unlikely, because the cell clone must be adapted to survive a physical transmission of living cells between hosts, and must be able to survive in the environment of a new host's immune system.[12] Animals that have undergone population bottlenecks may be at greater risks of contracting transmissible cancers due to a lack of overall genetic diversity. Infectious cancers may also evolve to circumvent immune response by means of natural selection in order to spread.[13] Because of their transmission, it was initially thought that these diseases were caused by the transfer of oncoviruses, in the manner of cervical cancer caused by human papillomavirus.[2] However, canine transmissible venereal tumor mutes the expression of the immune response, whereas the Syrian hamster disease spreads due to lack of genetic diversity.[14]

Canine transmissible venereal tumor

Main article: Canine transmissible venereal tumor

Canine transmissible venereal tumor (CTVT) is sexually transmitted cancer which induces cancerous tumors on the genitalia of both male and female dogs, typically during mating. It was first described medically by a veterinary practitioner in London in 1810.[15] It was experimentally transplanted between dogs in 1876 by M. A. Novinsky (1841–1914). A single malignant clone of CTVT cells has colonized dogs worldwide, representing the oldest known malignant cell line in continuous propagation,[16] a fact that was uncovered in 2006. Researchers deduced that the CTVT went through 2 million mutations to reach its actual state, and inferred it started to develop in ancient dog species 11 000 years ago.[15]

Contagious reticulum cell sarcoma

Main article: Contagious reticulum cell sarcoma

Contagious reticulum cell sarcoma of the Syrian hamster[17] can be transmitted from one Syrian hamster to another through various mechanisms. It has been seen to spread within a laboratory population, presumably through gnawing at tumours and cannibalism.[1] It can also be spread by means of the bite of the mosquito Aedes aegypti.[18]

Devil facial tumour disease

Main article: Devil facial tumour disease

Devil facial tumour disease (DFTD) is a transmissible parasitic cancer in the Tasmanian devil.[19] Since its discovery in 1996, DFTD has spread and infected 4/5 of all Tasmanian devils and threatens them with extinction. DFTD has a near 100% fatality rate, and has killed up to 90% of Tasmanian devil populations living in some reserves.[20] A new DFTD tumor-type cancer was recently uncovered on 5 Tasmanian devils (DFT2), histologically different from DFT1, leading researchers to believe that the Tasmanian devil "is particularly prone to the emergence of transmissible cancers".[15]

Bivalves

Soft-shell clams, Mya arenaria, have been found to be vulnerable to a transmissible neoplasm of the hemolymphatic system — effectively, leukemia.[21][22] The cells have infected clam beds hundreds of miles from each other, making this clonally transmissible cancer the only one that does not require contact for transmission.[15]

Horizontally transmitted cancers have also been discovered in three other species of marine bivalves: bay mussels (Mytilus trossulus), common cockles (Cerastoderma edule) and golden carpet shell clams (Polititapes aureus). The golden carpet shell clam cancer was found to have been transmitted from another species, the pullet carpet shell (Venerupis corrugata).[23][24]

See also

References

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  3. ^ Barozzi P, Luppi M, Facchetti F, Mecucci C, Alù M, Sarid R, et al. (May 2003). "Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors". Nature Medicine. 9 (5): 554–61. doi:10.1038/nm862. PMID 12692543. S2CID 2527251.
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  6. ^ Gärtner HV, Seidl C, Luckenbach C, Schumm G, Seifried E, Ritter H, Bültmann B (November 1996). "Genetic analysis of a sarcoma accidentally transplanted from a patient to a surgeon". The New England Journal of Medicine. 335 (20): 1494–6. doi:10.1056/NEJM199611143352004. PMID 8890100.
  7. ^ Gugel EA, Sanders ME (December 1986). "Needle-stick transmission of human colonic adenocarcinoma". The New England Journal of Medicine. 315 (23): 1487. doi:10.1056/NEJM198612043152314. PMID 3785302.
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  9. ^ Ní Leathlobhair M, Gulland FM, Murchison EP (2017-06-22). "No evidence for clonal transmission of urogenital carcinoma in California sea lions ( Zalophus californianus)". Wellcome Open Research. 2: 46. doi:10.12688/wellcomeopenres.11483.1. PMC 5527528. PMID 28948233.
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  13. ^ Belov K (February 2011). "The role of the Major Histocompatibility Complex in the spread of contagious cancers". Mammalian Genome. 22 (1–2): 83–90. doi:10.1007/s00335-010-9294-2. PMID 20963591. S2CID 8303843.
  14. ^ Siddle HV, Kreiss A, Eldridge MD, Noonan E, Clarke CJ, Pyecroft S, et al. (October 2007). "Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial". Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16221–6. doi:10.1073/pnas.0704580104. PMC 1999395. PMID 17911263.
  15. ^ a b c d Harrison C (May 2018). "Clonally transmissible cancers in nature". Cancer Therapy Advisor. Retrieved 2019-10-03.
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