Tiglyl-CoA

Tiglyl-CoA
Names
	IUPAC name S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-2-methylbut-2-enethioate
Identifiers
CAS Number	6247-62-7 ;
3D model (JSmol)	Interactive image;
MeSH	tiglyl-coenzyme+A
PubChem CID	6443760;
CompTox Dashboard (EPA)	DTXSID101027515 ;
	SMILES C\C=C(/C)\C(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=CN=C3N)O)OP(=O)(O)O)O;
Properties
Chemical formula	C26H42N7O17P3S
Molar mass	849.63 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Tiglyl-CoA is an intermediate in the metabolism of isoleucine.^[1]^[2] It is an inhibitor of N-acetylglutamate synthetase.^[3]

References

^ ROBINSON WG; BACHHAWAT BK; COON MJ (1956). "TIGLYL COENZYME A AND a-METHYLACETOACETYL COENZYME A, INTERMEDIATES IN THE ENZYMATIC DEGRADATION OF ISOLEUCINE". Journal of Biological Chemistry. 218 (1): 391–400. PMID 13278346.
^ "Showing metabocard for Tiglyl-CoA (HMDB02054)". The Metabolomics Innovation Centre (TMIC).
^ Coude, F X; Sweetman, L; Nyhan, W L (1979). "Inhibition by propionyl-coenzyme A of N-acetylglutamate synthetase in rat liver mitochondria. A possible explanation for hyperammonemia in propionic and methylmalonic acidemia". Journal of Clinical Investigation. 64 (6): 1544–1551. doi:10.1172/JCI109614. PMC 371306. PMID 500823.

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