The Group C of the 1999 Copa América was one of the three groups of competing nations in the 1999 Copa América. It comprised Argentina, Colombia, Ecuador, and Uruguay. Group play began on July 1 and ended on July 7.
Colombia won the group and faced Chile, the best third-placed finisher, in the quarterfinals. Argentina finished second and faced Brazil, the winners of Group B, in the quarterfinals. Uruguay finished third and faced Paraguay, the winner of Group A, in the quarterfinals. Ecuador finished fourth in the group and was eliminated from the tournament.