POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1gene.[5][6] The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1.[7] BOB1 is a transcriptional coactivator (i.e. a protein that controls the activity of transcription factors) which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36.[8] The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas,[9] as exemplified in studies which use BAB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.[10]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Junker S, Brøndum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics. 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID8617501.
^Ponzoni M, Arrigoni G, Doglioni C (January 2007). "New transcription factors in diagnostic hematopathology". Advances in Anatomic Pathology. 14 (1): 25–35. doi:10.1097/PAP.0b013e31802f0495. PMID17198308.
^Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z (November 2016). "Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers". Histopathology. 69 (5): 775–783. doi:10.1111/his.13017. PMID27319306.
^Grimm KE, O'Malley DP (February 2019). "Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues". Annals of Diagnostic Pathology. 38: 6–10. doi:10.1016/j.anndiagpath.2018.09.014. PMID30380402.
^Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (Jun 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID11380252.
Gstaiger M, Knoepfel L, Georgiev O, Schaffner W, Hovens CM (1995). "A B-cell coactivator of octamer-binding transcription factors". Nature. 373 (6512): 360–2. doi:10.1038/373360a0. PMID7779176.
Strubin M, Newell JW, Matthias P (1995). "OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins". Cell. 80 (3): 497–506. doi:10.1016/0092-8674(95)90500-6. PMID7859290.
Galiègue-Zouitina S, Quief S, Hildebrand MP, Denis C, Lecocq G, Collyn-d'Hooghe M, Bastard C, Yuille M, Dyer MJ, Kerckaert JP (1996). "Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation". Comptes Rendus de l'Académie des Sciences, Série III. 318 (11): 1125–31. PMID8574789.
Zwilling S, Dieckmann A, Pfisterer P, Angel P, Wirth T (1997). "Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells". Science. 277 (5323): 221–5. doi:10.1126/science.277.5323.221. PMID9211847.
Sauter P, Matthias P (1998). "The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction". Immunobiology. 198 (1–3): 207–16. doi:10.1016/S0171-2985(97)80041-1. PMID9442392.
Tomilin A, Reményi A, Lins K, Bak H, Leidel S, Vriend G, Wilmanns M, Schöler HR (2001). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration". Cell. 103 (6): 853–64. doi:10.1016/S0092-8674(00)00189-6. PMID11136971.
Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID11380252.
Casellas R, Jankovic M, Meyer G, Gazumyan A, Luo Y, Roeder R, Nussenzweig M (2003). "OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes". Cell. 110 (5): 575–85. doi:10.1016/S0092-8674(02)00911-X. PMID12230975.