From Wikipedia, the free encyclopedia
Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene .[ 4] [ 5] It located on chromosome 2 next to KIAA1841
Interactions
PEX13 has been shown to interact with PEX14 ,[ 6] PEX5 [ 6] [ 7] and PEX19 .[ 8] [ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000162928 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Björkman J, Stetten G, Moore CS, Gould SJ, Crane DI (December 1998). "Genomic structure of PEX13, a candidate peroxisome biogenesis disorder gene". Genomics . 54 (3): 521–8. doi :10.1006/geno.1998.5520 . PMID 9878256 .
^ "Entrez Gene: PEX13 peroxisome biogenesis factor 13" .
^ a b Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import" . Molecular and Cellular Biology . 22 (6): 1639–55. doi :10.1128/MCB.22.6.1639-1655.2002 . PMC 135613 . PMID 11865044 .
^ Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor" . The Journal of Cell Biology . 135 (1): 85–95. doi :10.1083/jcb.135.1.85 . PMC 2121023 . PMID 8858165 .
^ Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis" . The Journal of Cell Biology . 148 (5): 931–44. doi :10.1083/jcb.148.5.931 . PMC 2174547 . PMID 10704444 .
^ Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences" . Molecular and Cellular Biology . 21 (13): 4413–24. doi :10.1128/MCB.21.13.4413-4424.2001 . PMC 87101 . PMID 11390669 .
Further reading
Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor" . The Journal of Cell Biology . 135 (1): 85–95. doi :10.1083/jcb.135.1.85 . PMC 2121023 . PMID 8858165 .
Albertini M, Rehling P, Erdmann R, Girzalsky W, Kiel JA, Veenhuis M, Kunau WH (April 1997). "Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways". Cell . 89 (1): 83–92. doi :10.1016/S0092-8674(00)80185-3 . PMID 9094717 .
Fransen M, Terlecky SR, Subramani S (July 1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import" . Proceedings of the National Academy of Sciences of the United States of America . 95 (14): 8087–92. Bibcode :1998PNAS...95.8087F . doi :10.1073/pnas.95.14.8087 . PMC 20933 . PMID 9653144 .
Girzalsky W, Rehling P, Stein K, Kipper J, Blank L, Kunau WH, Erdmann R (March 1999). "Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes" . The Journal of Cell Biology . 144 (6): 1151–62. doi :10.1083/jcb.144.6.1151 . PMC 2150583 . PMID 10087260 .
Shimozawa N, Suzuki Y, Zhang Z, Imamura A, Toyama R, Mukai S, et al. (June 1999). "Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders" . Human Molecular Genetics . 8 (6): 1077–83. doi :10.1093/hmg/8.6.1077 . PMID 10332040 .
Toyama R, Mukai S, Itagaki A, Tamura S, Shimozawa N, Suzuki Y, et al. (September 1999). "Isolation, characterization and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants" . Human Molecular Genetics . 8 (9): 1673–81. doi :10.1093/hmg/8.9.1673 . PMID 10441330 .
Liu Y, Björkman J, Urquhart A, Wanders RJ, Crane DI, Gould SJ (September 1999). "PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders" . American Journal of Human Genetics . 65 (3): 621–34. doi :10.1086/302534 . PMC 1377968 . PMID 10441568 .
Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis" . The Journal of Cell Biology . 148 (5): 931–44. doi :10.1083/jcb.148.5.931 . PMC 2174547 . PMID 10704444 .
Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences" . Molecular and Cellular Biology . 21 (13): 4413–24. doi :10.1128/MCB.21.13.4413-4424.2001 . PMC 87101 . PMID 11390669 .
Jones JM, Morrell JC, Gould SJ (June 2001). "Multiple distinct targeting signals in integral peroxisomal membrane proteins" . The Journal of Cell Biology . 153 (6): 1141–50. doi :10.1083/jcb.153.6.1141 . PMC 2192020 . PMID 11402059 .
Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import" . Molecular and Cellular Biology . 22 (6): 1639–55. doi :10.1128/MCB.22.6.1639-1655.2002 . PMC 135613 . PMID 11865044 .
Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP (March 2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay" . Molecular & Cellular Proteomics . 1 (3): 243–52. doi :10.1074/mcp.M100025-MCP200 . PMID 12096124 .
Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP (March 2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes" . The Journal of Biological Chemistry . 279 (13): 12615–24. doi :10.1074/jbc.M304941200 . PMID 14715663 .
Hashimoto K, Kato Z, Nagase T, Shimozawa N, Kuwata K, Omoya K, et al. (August 2005). "Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder" . Pediatric Research . 58 (2): 263–9. doi :10.1203/01.PDR.0000169984.89199.69 . PMID 16006427 .
Nguyen T, Bjorkman J, Paton BC, Crane DI (February 2006). "Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance" . Journal of Cell Science . 119 (Pt 4): 636–45. doi :10.1242/jcs.02776 . PMID 16449325 .
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