Pinin

PNN
Identifiers
Aliases	PNN, DRS, DRSP, SDK3, memA, Pinin, pinin, desmosome associated protein
External IDs	OMIM: 603154; MGI: 1100514; HomoloGene: 37656; GeneCards: PNN; OMA:PNN - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	39,183,220 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	59,120,784 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; corpus epididymis; ; sural nerve; ; epithelium of nasopharynx; ; ventricular zone; ; pylorus; ; internal globus pallidus; ; cardia; ; seminal vesicula; ; right uterine tube;
	Top expressed in
	medullary collecting duct; ; saccule; ; tail of embryo; ; neural layer of retina; ; renal corpuscle; ; otic placode; ; genital tubercle; ; fossa; ; primitive streak; ; condyle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; DNA binding; RNA binding; protein binding;
Cellular component	intermediate filament; cell junction; nucleus; cell-cell junction; membrane; desmosome; exon-exon junction complex; plasma membrane; catalytic step 2 spliceosome; spliceosomal complex; nuclear speck;
Biological process	mRNA splicing, via spliceosome; transcription, DNA-templated; RNA splicing; mRNA processing; regulation of transcription, DNA-templated; cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	5411
	18949
	ENSG00000100941
	ENSMUSG00000020994
	Q9H307
	O35691
	NM_002687
	NM_008891
	NP_002678
	NP_032917
	Wikidata
View/Edit Human	View/Edit Mouse

Pinin is a protein that in humans is encoded by the PNN gene.^[5]^[6]

Interactions

Pinin has been shown to interact with Keratin 8,^[7] Keratin 18,^[7] Keratin 19,^[7] CTBP1,^[8] RNPS1,^[9]^[10] PRPF4B,^[11] SFRS4,^[12] PPIG,^[13] SRRM2^[12] and SFRS18.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100941 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020994 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ouyang P, Sugrue SP (January 1997). "Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex". J Cell Biol. 135 (4): 1027–42. doi:10.1083/jcb.135.4.1027. PMC 2133386. PMID 8922384.
^ "Entrez Gene: PNN pinin, desmosome associated protein".
^ ^a ^b ^c Shi, J; Sugrue S P (May 2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus". J. Biol. Chem. 275 (20): 14910–5. doi:10.1074/jbc.275.20.14910. ISSN 0021-9258. PMID 10809736.
^ Alpatov, Roman; Munguba Gustavo Costa; Caton Paul; Joo Jeong Hoon; Shi Yang; Shi Yujiang; Hunt Marguerite E; Sugrue Stephen P (December 2004). "Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene". Mol. Cell. Biol. 24 (23): 10223–35. doi:10.1128/MCB.24.23.10223-10235.2004. ISSN 0270-7306. PMC 529029. PMID 15542832.
^ Ewing, Rob M; Chu Peter; Elisma Fred; Li Hongyan; Taylor Paul; Climie Shane; McBroom-Cerajewski Linda; Robinson Mark D; O'Connor Liam; Li Michael; Taylor Rod; Dharsee Moyez; Ho Yuen; Heilbut Adrian; Moore Lynda; Zhang Shudong; Ornatsky Olga; Bukhman Yury V; Ethier Martin; Sheng Yinglun; Vasilescu Julian; Abu-Farha Mohamed; Lambert Jean-Philippe; Duewel Henry S; Stewart Ian I; Kuehl Bonnie; Hogue Kelly; Colwill Karen; Gladwish Katharine; Muskat Brenda; Kinach Robert; Adams Sally-Lin; Moran Michael F; Morin Gregg B; Topaloglou Thodoros; Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Li, Chin; Lin Ru-Inn; Lai Ming-Chih; Ouyang Pin; Tarn Woan-Yuh (October 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Mol. Cell. Biol. 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. ISSN 0270-7306. PMC 230327. PMID 14517304.
^ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (July 2002). "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes". Mol. Cell. Biol. 22 (14): 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. ISSN 0270-7306. PMC 139773. PMID 12077342.
^ ^a ^b ^c Zimowska, Grazyna; Shi Jia; Munguba Gustavo; Jackson Moira R; Alpatov Roman; Simmons Matthew N; Shi Yujiang; Sugrue Stephen P (November 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi:10.1167/iovs.03-0240. ISSN 0146-0404. PMID 14578391.
^ Lin, Chun Lun; Leu Steve; Lu Ming Chu; Ouyang Pin (August 2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles". Biochem. Biophys. Res. Commun. 321 (3): 638–47. doi:10.1016/j.bbrc.2004.07.013. ISSN 0006-291X. PMID 15358154.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Brandner JM, Reidenbach S, Franke WW (1998). "Evidence that "pinin", reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein". Differentiation. 62 (3): 119–27. doi:10.1046/j.1432-0436.1997.6230119.x. PMID 9447706.
Degen WG, Agterbos MA, Muyrers JP, et al. (1999). "memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3". Biochim. Biophys. Acta. 1444 (3): 384–94. doi:10.1016/s0167-4781(99)00012-3. PMID 10095061.
Ouyang P (1999). "Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus". Biochem. Biophys. Res. Commun. 263 (1): 192–200. doi:10.1006/bbrc.1999.1353. PMID 10486276.
Shi Y, Ouyang P, Sugrue SP (2000). "Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function". Oncogene. 19 (2): 289–97. doi:10.1038/sj.onc.1203328. PMID 10645008.
Shi J, Sugrue SP (2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus". J. Biol. Chem. 275 (20): 14910–5. doi:10.1074/jbc.275.20.14910. PMID 10809736.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Wang P, Lou PJ, Leu S, Ouyang P (2002). "Modulation of alternative pre-mRNA splicing in vivo by pinin". Biochem. Biophys. Res. Commun. 294 (2): 448–55. doi:10.1016/S0006-291X(02)00495-3. PMID 12051732.
Dellaire G, Makarov EM, Cowger JJ, et al. (2002). "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes". Mol. Cell. Biol. 22 (14): 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. PMC 139773. PMID 12077342.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chang WL, Lee DC, Leu S, et al. (2003). "Molecular characterization of a novel nucleolar protein, pNO40". Biochem. Biophys. Res. Commun. 307 (3): 569–77. doi:10.1016/S0006-291X(03)01208-7. PMID 12893261.
Li C, Lin RI, Lai MC, et al. (2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Mol. Cell. Biol. 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. PMC 230327. PMID 14517304.
Zimowska G, Shi J, Munguba G, et al. (2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi:10.1167/iovs.03-0240. PMID 14578391.
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Lin CL, Leu S, Lu MC, Ouyang P (2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles". Biochem. Biophys. Res. Commun. 321 (3): 638–47. doi:10.1016/j.bbrc.2004.07.013. PMID 15358154.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100941 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020994 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8922384-5] Ouyang P, Sugrue SP (January 1997). "Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex". J Cell Biol. 135 (4): 1027–42. doi:10.1083/jcb.135.4.1027. PMC 2133386. PMID 8922384.

[entrez-6] "Entrez Gene: PNN pinin, desmosome associated protein".

[pmid10809736-7] Shi, J; Sugrue S P (May 2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus". J. Biol. Chem. 275 (20): 14910–5. doi:10.1074/jbc.275.20.14910. ISSN 0021-9258. PMID 10809736.

[pmid15542832-8] Alpatov, Roman; Munguba Gustavo Costa; Caton Paul; Joo Jeong Hoon; Shi Yang; Shi Yujiang; Hunt Marguerite E; Sugrue Stephen P (December 2004). "Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene". Mol. Cell. Biol. 24 (23): 10223–35. doi:10.1128/MCB.24.23.10223-10235.2004. ISSN 0270-7306. PMC 529029. PMID 15542832.

[pmid17353931-9] Ewing, Rob M; Chu Peter; Elisma Fred; Li Hongyan; Taylor Paul; Climie Shane; McBroom-Cerajewski Linda; Robinson Mark D; O'Connor Liam; Li Michael; Taylor Rod; Dharsee Moyez; Ho Yuen; Heilbut Adrian; Moore Lynda; Zhang Shudong; Ornatsky Olga; Bukhman Yury V; Ethier Martin; Sheng Yinglun; Vasilescu Julian; Abu-Farha Mohamed; Lambert Jean-Philippe; Duewel Henry S; Stewart Ian I; Kuehl Bonnie; Hogue Kelly; Colwill Karen; Gladwish Katharine; Muskat Brenda; Kinach Robert; Adams Sally-Lin; Moran Michael F; Morin Gregg B; Topaloglou Thodoros; Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid14517304-10] Li, Chin; Lin Ru-Inn; Lai Ming-Chih; Ouyang Pin; Tarn Woan-Yuh (October 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Mol. Cell. Biol. 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. ISSN 0270-7306. PMC 230327. PMID 14517304.

[pmid12077342-11] Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (July 2002). "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes". Mol. Cell. Biol. 22 (14): 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. ISSN 0270-7306. PMC 139773. PMID 12077342.

[pmid14578391-12] Zimowska, Grazyna; Shi Jia; Munguba Gustavo; Jackson Moira R; Alpatov Roman; Simmons Matthew N; Shi Yujiang; Sugrue Stephen P (November 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi:10.1167/iovs.03-0240. ISSN 0146-0404. PMID 14578391.

[pmid15358154-13] Lin, Chun Lun; Leu Steve; Lu Ming Chu; Ouyang Pin (August 2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles". Biochem. Biophys. Res. Commun. 321 (3): 638–47. doi:10.1016/j.bbrc.2004.07.013. ISSN 0006-291X. PMID 15358154.

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Interactions

References

Further reading