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John Ioannidis

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John P. A. Ioannidis
Born (1965-08-21) August 21, 1965 (age 59)
New York City, U.S.
NationalityAmerican, Greek
Alma materUniversity of Athens Medical School
Athens College
Known forMetascience
Scientific career
FieldsMedicine, metascience
InstitutionsStanford School of Medicine

John P. A. Ioannidis (/ˌiəˈniːdəs/; born August 21, 1965) is a Greek-American physician-scientist and writer who has made contributions to evidence-based medicine, epidemiology, and clinical research. Ioannidis studies scientific research itself, meta-research primarily in clinical medicine and the social sciences. Ioannidis is a Professor of Medicine, of Health Research and Policy and of Biomedical Data Science, at Stanford University School of Medicine and a Professor, by courtesy, of Statistics at Stanford University School of Humanities and Sciences.

Early life and education

Ioannidis (2005) Why Most Published Research Findings Are False.[1]

Born in New York City in 1965, Ioannidis was raised in Athens, Greece.[2] He was Valedictorian of his class at Athens College, graduating in 1984, and won a number of awards, including the National Award of the Greek Mathematical Society.[3] He graduated in the top rank of his class at the University of Athens Medical School, then attended Harvard University for his medical residency in internal medicine. He did a fellowship at Tufts University for infectious disease.[4]

Career

From 1998 to 2010, he was chairman of the Department of Hygiene and Epidemiology, University of Ioannina School of Medicine. In 2002 he became an adjunct professor at Tufts University School of Medicine.[5][3] He has also been President of the Society for Research Synthesis Methodology.[3] He is highly-cited, having an h-index of 196 on Google Scholar in 2020.[6]

Ioannidis is now Professor of Medicine, Health Research and Policy and of Biomedical Data Science, at Stanford University School of Medicine and a Professor, by courtesy, of Statistics at Stanford University School of Humanities and Sciences.[7][8] He is director of the Stanford Prevention Research Center, and co-director, along with Steven N. Goodman, of the Meta-Research Innovation Center at Stanford (METRICS).[9][10]

He was the editor-in-chief of the European Journal of Clinical Investigation from 2010 to 2019.[11]

Awards

Ioannidis has received numerous awards and honorary titles and he is a member of the US National Academy of Medicine,[12] of the European Academy of Sciences and Arts and an Einstein Fellow. In 2019, Ioannidis was awarded the NIH's Robert S. Gordon, Jr. Lecture in Epidemiology.[13]

Press coverage

In 2010, The Atlantic wrote a lengthy piece on Ioannidis, as a part of a special edition about "Brave Thinkers".[14][15]

In 2014, The Economist wrote a shorter piece about the foundation, by Ioannidis and Steven Goodman, of the Meta-Research Innovation Centre at Stanford.[16]

In 2015, he was profiled in the BMJ and described as "the scourge of sloppy science".[17]

In a 2020 editorial on STAT, Ioannidis criticized the lack of informed decision-making in the global response to the COVID-19 pandemic, calling it a "once-in-a-century evidence fiasco."[8]

Research

Further information: Metascience

Ioannidis's 2005 paper "Why Most Published Research Findings Are False"[1] is the most downloaded paper in the Public Library of Science[18][19] and is considered foundational to the field of metascience.[20] In the paper, Ioannidis demonstrates that most published research does not meet good scientific standards of evidence. Ioannidis has also addressed the replication crisis in diverse scientific fields including genetics,[21] clinical trials,[22] and neuroscience.[23] His work has aimed to identify solutions to problems in research, and on how to perform research more optimally.[24][25]

Ioannidis's research at Stanford focusses on meta-analysis and meta-research – the study of studies.[26] Thomas Trikalinos and Ioannidis coined the term Proteus phenomenon to describe tendency for early studies on a subject to find larger effect than later ones.[27]

Covid-19 research

John Ioannidis' commentary on the COVID-19 pandemic has been the subject of increased media attention as well as objections from other researchers since the beginning of 2020.[28] Ioannidis was a co-author in the study "COVID-19 Antibody Seroprevalence in Santa Clara County, California" released in April 17 of 2020, which has drawn conclusions disputed by other scholars.[29] It was also reported that authors of the study received funding from JetBlue's founder, which led to criticism over a potential conflict of interest.[30][31][32]

See also

References

  1. ^ a b Ioannidis, J. P. A. (2005). "Why Most Published Research Findings Are False". PLoS Medicine. 2 (8): e124. doi:10.1371/journal.pmed.0020124. PMC 1182327. PMID 16060722.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  2. ^ John Ioannidis Harvard School of Public Health
  3. ^ a b c Ioannidis, John P.A.n. "Curriculum Vitae" (PDF). Archived from the original (PDF) on July 21, 2011. Retrieved November 4, 2010.
  4. ^ David H. Freedman (2010). Wrong: Why Experts Keep Failing Us. Little, Brown and Company. ISBN 978-0-316-02378-8. Born in 1965 in the United States to parents who were both physicians, he was raised in Athens, where he showed unusual aptitude in mathematics and snagged Greece's top student math prize. ...
  5. ^ "John P.A. Ioannidis". Department of Hygiene and Epidemiology, University of Ioannina School of Medicine. Retrieved December 31, 2008.
  6. ^ Philip Chrysopoulos (6 May 2020), "Two Greek Scientists Among Most Highly Cited in the World", Greek Reporter
  7. ^ "John P.A. Ioannidis". Stanford Profiles. Retrieved 24 April 2020.
  8. ^ a b "A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data". STAT. 17 March 2020. Retrieved 26 April 2020.
  9. ^ "John P. A. Ioannidis". CAP Profiles. Stanford School of Medicine. Retrieved May 24, 2014.
  10. ^ "Prevention Research Center". Stanford School of Medicine. Retrieved May 24, 2014.
  11. ^ "John Ioannidis". Stanford. Retrieved 2020-04-21.{{cite web}}: CS1 maint: url-status (link)
  12. ^ "National Academy of Medicine Elects 85 New Members". National Academy of Medicine. 15 October 2018. Retrieved 2 May 2019.
  13. ^ "2019 Awardee". Office of Disease Prevention. Retrieved 22 April 2020.
  14. ^ David H. Freedman (2010). "Lies, damned lies, and medical science". The Atlantic. Vol. 306, no. 4. pp. 76–84.
  15. ^ "Brave Thinkers", The Atlantic, 2010
  16. ^ "Combating bad science: Metaphysicians". The Economist.
  17. ^ Ioannidis, J. (2015). "John Ioannidis: Uncompromising gentle maniac". BMJ. 351: h4992. doi:10.1136/bmj.h4992. ISSN 1756-1833. PMID 26404555.
  18. ^ "Highly Cited Researchers". Retrieved September 17, 2015.
  19. ^ Medicine - Stanford Prevention Research Center. John P.A. Ioannidis
  20. ^ Robert Lee Hotz (September 14, 2007). "Most Science Studies Appear to Be Tainted By Sloppy Analysis". Wall Street Journal. Dow Jones & Company. Retrieved 2016-12-05.
  21. ^ Ioannidis, John P. A.; Ntzani, Evangelia E.; Trikalinos, Thomas A.; Contopoulos-Ioannidis, Despina G. (November 1, 2001). "Replication validity of genetic association studies". Nature Genetics. 29 (3): 306–309. doi:10.1038/ng749. ISSN 1061-4036. PMID 11600885.
  22. ^ Ebrahim, Shanil; Sohani, Zahra N.; Montoya, Luis; Agarwal, Arnav; Thorlund, Kristian; Mills, Edward J.; Ioannidis, John P. A. (September 10, 2014). "REanalyses of randomized clinical trial data". JAMA. 312 (10): 1024–1032. doi:10.1001/jama.2014.9646. ISSN 0098-7484. PMID 25203082.
  23. ^ Button, Katherine S.; Ioannidis, John P. A.; Mokrysz, Claire; Nosek, Brian A.; Flint, Jonathan; Robinson, Emma S. J.; Munafò, Marcus R. (May 1, 2013). "Power failure: why small sample size undermines the reliability of neuroscience". Nature Reviews Neuroscience. 14 (5): 365–376. doi:10.1038/nrn3475. ISSN 1471-003X. PMID 23571845.
  24. ^ Begley, C. Glenn; Ioannidis, John P. A. (January 2, 2015). "Reproducibility in science: improving the standard for basic and preclinical research". Circulation Research. 116 (1): 116–126. doi:10.1161/CIRCRESAHA.114.303819. ISSN 1524-4571. PMID 25552691.
  25. ^ Ioannidis, John P. A. (October 21, 2014). "How to Make More Published Research True". PLoS Med. 11 (10): e1001747. doi:10.1371/journal.pmed.1001747. PMC 4204808. PMID 25334033.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  26. ^ Joan O’C. Hamilton (2012), "Something Doesn't Add Up", Stanford Magazine
  27. ^ Handbook of Meta-analysis in Ecology and Evolution, Princeton University Press, 2013, p. 240, ISBN 9780691137292
  28. ^ Freedman, David. "A Prophet of Scientific Rigor—and a Covid Contrarian". Wired. Retrieved 24 May 2020.
  29. ^ Rushton, Josh. "Concerns with that Stanford study of coronavirus prevalence". Statistical Modeling, Causal Inference, and Social Science. Columbia University. Retrieved 24 May 2020.
  30. ^ Lee, Stephanie. "JetBlue's Founder Helped Fund A Stanford Study That Said The Coronavirus Wasn't That Deadly". Buzzfeed. Retrieved 30 May 2020.
  31. ^ Sherriff, Lucy. "JetBlue chief David Neeleman 'funded study downplaying virus death rate' after slamming lockdown as bad for business". The U.S. Sun. Retrieved 30 May 2020.
  32. ^ Landsverk, Gabby. "A controversial study on coronavirus was partly funded by an airline founder who's criticized lockdowns, according to a new investigation from BuzzFeed News". Business Insider. Retrieved 30 May 2020.
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