Fenpropathrin

Fenpropathrin
Clinical data
ATC code	None;
Identifiers
	IUPAC name [Cyano-(3-phenoxyphenyl)methyl] 2,2,3,3-tetramethylcyclopropane-1-carboxylate;
CAS Number	39515-41-8;
PubChem CID	47326;
ChemSpider	45352;
UNII	87BH96P0MX;
KEGG	C18411;
CompTox Dashboard (EPA)	DTXSID0024002 ;
ECHA InfoCard	100.049.514
Chemical and physical data
Formula	C22H23NO3
Molar mass	349.430 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1(C(C1(C)C)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C;
	InChI InChI=InChI=1S/C22H23NO3/c1-21(2)19(22(21,3)4)20(24)26-18(14-23)15-9-8-12-17(13-15)25-16-10-6-5-7-11-16/h5-13,18-19H,1-4H3; Key:XQUXKZZNEFRCAW-UHFFFAOYSA-N;

Fenpropathrin (brand names Danitol, Meothrin), or fenopropathrin, is a widely used pyrethroid insecticide in agriculture and household.^[1]^[2]^[3]^[4]

A person developed Parkinson's disease after six months of daily exposure to fenpropathrin, and animal tests subsequently revealed that the compound is a dopaminergic neurotoxin.^[4] It has thus been implicated as an environmental risk factor for Parkinson's disease.^[4]

References

^ Aizawa, Hiroyasu (2 December 2012). Metabolic Maps of Pesticides. Elsevier Science. pp. 185–. ISBN 978-0-323-15753-7. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
^ Abou-Donia, Mohamed B. (15 July 1992). Neurotoxicology. CRC Press. pp. 462–. ISBN 978-1-4398-0542-8. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
^ Johansen, Carl A.; Mayer, Daniel F. (1990). Pollinator Protection: A Bee & Pesticide Handbook. Wicwas Press. ISBN 978-1-878075-00-0. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
^ ^a ^b ^c Xiong J, Zhang X, Huang J, Chen C, Chen Z, Liu L, et al. (March 2016). "Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration". Molecular Neurobiology. 53 (2): 995–1008. doi:10.1007/s12035-014-9057-2. PMC 5333774. PMID 25575680.

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[Aizawa2012-1] Aizawa, Hiroyasu (2 December 2012). Metabolic Maps of Pesticides. Elsevier Science. pp. 185–. ISBN 978-0-323-15753-7. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[Abou-Donia1992-2] Abou-Donia, Mohamed B. (15 July 1992). Neurotoxicology. CRC Press. pp. 462–. ISBN 978-1-4398-0542-8. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[JohansenMayer1990-3] Johansen, Carl A.; Mayer, Daniel F. (1990). Pollinator Protection: A Bee & Pesticide Handbook. Wicwas Press. ISBN 978-1-878075-00-0. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[XiongZhang2015-4] Xiong J, Zhang X, Huang J, Chen C, Chen Z, Liu L, et al. (March 2016). "Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration". Molecular Neurobiology. 53 (2): 995–1008. doi:10.1007/s12035-014-9057-2. PMC 5333774. PMID 25575680.

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v t e Pesticides
Pesticide types	Acaricide Bactericide Biocide Bioherbicide Biopesticide Fungicide Herbicide Defoliant Insecticide Molluscicide Nematicide Piscicide Rodenticide Slimicide
Related topics	Health effects Environmental effects Fumigation Agricultural spray adjuvant Biological pest control Gene silencing Integrated pest management Maximum residue limit Non-pesticide management Persistent organic pollutant Pest control Application Drift Formulation Degradation Misuse Paradox of the pesticides Poisoning Research Residue Resistance Bee toxicity Restricted use Pesticide Action Network Silent Spring The Pesticide Question Toxicity class
By country	Canada European Union New Zealand United States
Integrated Pest Management Index of pesticide articles Pesticide categories

v t e Monoamine neurotoxins
Adrenergic	DSP-4 Oxidopamine (6-OHDA)
Dopaminergic	Fenpropathrin Methamphetamine MPP⁺ MPTP Norsalsolinol Oxidopamine (6-OHDA) Rotenone Salsolinol
Serotonergic	3-CA 4-CAB 5,7-DHT α-Me-DA (3,4-DHA) αET αMT DCA MDA (tenamfetamine) MDMA (midomafetamine) PBA PCA PIA
See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine metabolism modulators

See also

References