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SF3B3

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SF3B3
Identifiers
AliasesSF3B3, RSE1, SAP130, SF3b130, STAF130, splicing factor 3b subunit 3
External IDsOMIM: 605592; MGI: 1289341; HomoloGene: 6579; GeneCards: SF3B3; OMA:SF3B3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012426

NM_133953

RefSeq (protein)

NP_036558

NP_598714

Location (UCSC)Chr 16: 70.52 – 70.58 MbChr 8: 111.54 – 111.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.[5][6]

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.[6]

Interactions

SF3B3 has been shown to interact with SF3B1,[5][7] Transcription initiation protein SPT3 homolog[8] and TAF9.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000189091Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033732Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Das BK; Xia L; Palandjian L; Gozani O; Chyung Y; Reed R (February 2000). "Characterization of a Protein Complex Containing Spliceosomal Proteins SAPs 49, 130, 145, and 155". Mol Cell Biol. 19 (10): 6796–802. doi:10.1128/mcb.19.10.6796. PMC 84676. PMID 10490618.
  6. ^ a b "Entrez Gene: SF3B3 splicing factor 3b, subunit 3, 130kDa".
  7. ^ Will, Cindy L; Urlaub Henning; Achsel Tilmann; Gentzel Marc; Wilm Matthias; Lührmann Reinhard (September 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. ISSN 0261-4189. PMC 126279. PMID 12234937.
  8. ^ a b Martinez, E; Palhan V B; Tjernberg A; Lymar E S; Gamper A M; Kundu T K; Chait B T; Roeder R G (October 2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856. PMID 11564863.

Further reading