YWHAH

YWHAH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C63, 2C74
Identifiers
Aliases	YWHAH, YWHA1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
External IDs	OMIM: 113508; MGI: 109194; HomoloGene: 37767; GeneCards: YWHAH; OMA:YWHAH - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.3 Start 31,944,522 bp End 31,957,603 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B1 Start 33,176,160 bp End 33,185,310 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole Brodmann area 10 paraflocculus of cerebellum middle frontal gyrus right frontal lobe cingulate gyrus anterior cingulate cortex dorsolateral prefrontal cortex orbitofrontal cortex amygdala Top expressed in primary visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex hippocampus proper superior frontal gyrus hypothalamus olfactory bulb neural layer of retina neural tube mesencephalon More reference expression data BioGPS n/a
Gene ontology Molecular function sodium channel regulator activity insulin-like growth factor receptor binding transmembrane transporter binding protein domain specific binding protein binding glucocorticoid receptor binding protein heterodimerization activity enzyme binding actin binding identical protein binding Cellular component cytoplasm cytosol intercalated disc plasma membrane extracellular exosome cytoplasmic vesicle membrane mitochondrion presynapse glutamatergic synapse Biological process regulation of neuron differentiation glucocorticoid catabolic process membrane depolarization during action potential substantia nigra development regulation of sodium ion transport regulation of synaptic plasticity positive regulation of transcription, DNA-templated positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway negative regulation of dendrite morphogenesis regulation of sodium ion transmembrane transporter activity membrane organization intracellular protein transport glucocorticoid receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7533 22629 Ensembl ENSG00000128245 ENSMUSG00000018965 UniProt Q04917 P68510 RefSeq (mRNA) NM_003405 NM_011738 RefSeq (protein) NP_003396 NP_035868 Location (UCSC) Chr 22: 31.94 – 31.96 Mb Chr 5: 33.18 – 33.19 Mb PubMed search
Wikidata
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14-3-3 protein eta is a protein that in humans is encoded by the YWHAH gene.

Function

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia.

Interactions

YWHAH has been shown to interact with:

• C-Raf,
• CDC25B,
• EPB41L3,
• Glucocorticoid receptor,
• KIF5B,
• KLC3,
• Phosphoinositide-dependent kinase-1,
• RIMS1,
• RIMS2,
• TLX2,
• TNFAIP3, and
• ZFP36.

Further reading

• Kino T, Pavlakis GN (Apr 2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA and Cell Biology. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
• Kino T, Chrousos GP (Jun 2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Annals of the New York Academy of Sciences. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.
• Ichimura-Ohshima Y, Morii K, Ichimura T, Araki K, Takahashi Y, Isobe T, Minoshima S, Fukuyama R, Shimizu N, Kuwano R (Apr 1992). "cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain". Journal of Neuroscience Research. 31 (4): 600–5. doi:10.1002/jnr.490310403. PMID 1578511.
• Ichimura T, Isobe T, Okuyama T, Takahashi N, Araki K, Kuwano R, Takahashi Y (Oct 1988). "Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases". Proceedings of the National Academy of Sciences of the United States of America. 85 (19): 7084–8. doi:10.1073/pnas.85.19.7084. PMC 282128. PMID 2902623.
• Ichimura T, Uchiyama J, Kunihiro O, Ito M, Horigome T, Omata S, Shinkai F, Kaji H, Isobe T (Dec 1995). "Identification of the site of interaction of the 14-3-3 protein with phosphorylated tryptophan hydroxylase". The Journal of Biological Chemistry. 270 (48): 28515–8. doi:10.1074/jbc.270.48.28515. PMID 7499362.
• Jones DH, Ley S, Aitken A (Jul 1995). "Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins". FEBS Letters. 368 (1): 55–8. doi:10.1016/0014-5793(95)00598-4. PMID 7615088.
• Wu C, Friedlander P, Lamoureux C, Zannis-Hadjopoulos M, Price GB (Sep 1993). "cDNA clones contain autonomous replication activity". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1174 (3): 241–57. doi:10.1016/0167-4781(93)90193-h. PMID 7690594.
• Swanson KD, Dhar MS, Joshi JG (Oct 1993). "The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1216 (1): 145–8. doi:10.1016/0167-4781(93)90053-G. PMID 8218406.
• Leffers H, Madsen P, Rasmussen HH, Honoré B, Andersen AH, Walbum E, Vandekerckhove J, Celis JE (Jun 1993). "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway". Journal of Molecular Biology. 231 (4): 982–98. doi:10.1006/jmbi.1993.1346. PMID 8515476.
• Muratake T, Hayashi S, Ichimura Y, Morii K, Kuwano R, Ichikawa T, Kumanishi T, Isobe T, Watanabe M, Kondo H (1996). "The effect on methamphetamine on the mRNA level for 14.3.3 eta chain in the human cultured cells". Molecular Neurobiology. 11 (1–3): 223–30. doi:10.1007/BF02740697. PMID 8561965.
• Tommerup N, Leffers H (Apr 1996). "Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization". Genomics. 33 (1): 149–50. doi:10.1006/geno.1996.0176. PMID 8617504.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Papin C, Denouel A, Calothy G, Eychène A (May 1996). "Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system". Oncogene. 12 (10): 2213–21. PMID 8668348.
• Vincenz C, Dixit VM (Aug 1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". The Journal of Biological Chemistry. 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. PMID 8702721.
• Muratake T, Hayashi S, Ichikawa T, Kumanishi T, Ichimura Y, Kuwano R, Isobe T, Wang Y, Minoshima S, Shimizu N, Takahashi Y (Aug 1996). "Structural organization and chromosomal assignment of the human 14-3-3 eta chain gene (YWHAH)". Genomics. 36 (1): 63–9. doi:10.1006/geno.1996.0426. PMID 8812417.
• Wakui H, Wright AP, Gustafsson J, Zilliacus J (Mar 1997). "Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein". The Journal of Biological Chemistry. 272 (13): 8153–6. doi:10.1074/jbc.272.13.8153. PMID 9079630.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H (Sep 1997). "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science. 277 (5331): 1501–5. doi:10.1126/science.277.5331.1501. PMID 9278512.
• De Valck D, Heyninck K, Van Criekinge W, Vandenabeele P, Fiers W, Beyaert R (Sep 1997). "A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins". Biochemical and Biophysical Research Communications. 238 (2): 590–4. doi:10.1006/bbrc.1997.7343. PMID 9299557.
• Hsu SY, Kaipia A, Zhu L, Hsueh AJ (Nov 1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11". Molecular Endocrinology. 11 (12): 1858–67. doi:10.1210/me.11.12.1858. PMID 9369453.

External links

• Overview of all the structural information available in the PDB for UniProt: Q04917 (Human 14-3-3 protein eta) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: P68510 (Mouse 14-3-3 protein eta) at the PDBe-KB.