The 1972 South Carolina United States Senate election was held on November 7, 1972 to select the U.S. Senator from the state of South Carolina. Popular incumbent Republican Senator Strom Thurmond easily defeated Democratic challenger Eugene N. Zeigler.
The general election campaign was a lackluster affair as Thurmond was heavily favored to win re-election and he outspent Zeigler by a margin of four to one. However, Thurmond's re-election was almost derailed when his hometown newspaper, the Edgefield Advertiser, ran the headline "SEN. THURMOND IS UNPRINCIPLED WITH COLORED OFFSPRING WHILE PARADING AS A DEVOUT SEGREGATIONIST" on the October 11 front page. The Thurmond campaign fiercely denied that he had sired a black child and claimed that it was a dirty trick being played by the Zeigler campaign. While the allegation ultimately proved true, at the time it served to galvanize voters for Thurmond.