ADH5

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ADH5
Protein ADH5 PDB 1m6h.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p, alcohol dehydrogenase 5 (class III), chi polypeptide
External IDs MGI: 87929 HomoloGene: 68076 GeneCards: 128
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000671

NM_001288578
NM_007410

RefSeq (protein)

NP_000662.3

NP_001275507.1
NP_031436.2

Location (UCSC) Chr 4: 99.07 – 99.09 Mb Chr 3: 138.44 – 138.46 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Alcohol dehydrogenase class-3 is an enzyme that in humans is encoded by the ADH5 gene.[1][2][3]

This gene encodes glutathione-dependent formaldehyde dehydrogenase or class III alcohol dehydrogenase chi subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class III alcohol dehydrogenase is a homodimer composed of 2 chi subunits. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis.[3]

References[edit]

  1. ^ Hur MW, Edenberg HJ (Dec 1992). "Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase". Gene 121 (2): 305–11. doi:10.1016/0378-1119(92)90135-C. PMID 1446828. 
  2. ^ Adinolfi A, Adinolfi M, Hopkinson DA (May 1984). "Immunological and biochemical characterization of the human alcohol dehydrogenase chi-ADH isozyme". Ann Hum Genet 48 (Pt 1): 1–10. doi:10.1111/j.1469-1809.1984.tb00828.x. PMID 6424546. 
  3. ^ a b "Entrez Gene: ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide". 

Further reading[edit]