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Alcohol dehydrogenase 5 (class III), chi polypeptide
Protein ADH5 PDB 1m6h.png
PDB rendering based on 1m6h.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM103710 MGI87929 HomoloGene68076 ChEMBL: 4116 GeneCards: ADH5 Gene
EC number,
Species Human Mouse
Entrez 128 11532
Ensembl ENSG00000197894 ENSMUSG00000028138
UniProt P11766 P28474
RefSeq (mRNA) NM_000671 NM_001288578
RefSeq (protein) NP_000662 NP_001275507
Location (UCSC) Chr 4:
99.07 – 99.09 Mb
Chr 3:
138.44 – 138.46 Mb
PubMed search [1] [2]

Alcohol dehydrogenase class-3 is an enzyme that in humans is encoded by the ADH5 gene.[1][2][3]

This gene encodes glutathione-dependent formaldehyde dehydrogenase or class III alcohol dehydrogenase chi subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class III alcohol dehydrogenase is a homodimer composed of 2 chi subunits. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis.[3]


  1. ^ Hur MW, Edenberg HJ (Dec 1992). "Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase". Gene 121 (2): 305–11. doi:10.1016/0378-1119(92)90135-C. PMID 1446828. 
  2. ^ Adinolfi A, Adinolfi M, Hopkinson DA (May 1984). "Immunological and biochemical characterization of the human alcohol dehydrogenase chi-ADH isozyme". Ann Hum Genet 48 (Pt 1): 1–10. doi:10.1111/j.1469-1809.1984.tb00828.x. PMID 6424546. 
  3. ^ a b "Entrez Gene: ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide". 

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