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Available structures
PDBOrtholog search: PDBe RCSB
AliasesANAPC2, APC2, anaphase promoting complex subunit 2
External IDsOMIM: 606946 MGI: 2139135 HomoloGene: 8359 GeneCards: ANAPC2
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for ANAPC2
Genomic location for ANAPC2
Band9q34.3Start137,174,784 bp[1]
End137,188,560 bp[1]
RNA expression pattern
PBB GE ANAPC2 218555 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 9: 137.17 – 137.19 MbChr 2: 25.27 – 25.29 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.[5][6]

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.[6]


ANAPC2 has been shown to interact with ANAPC1[7][8] and ANAPC11.[5][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176248 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026965 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H (December 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol Biol Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.
  6. ^ a b "Entrez Gene: ANAPC2 anaphase promoting complex subunit 2".
  7. ^ Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947.
  8. ^ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.
  9. ^ Ohta, T; Michel J J; Schottelius A J; Xiong Y (April 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407.

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