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Adaptor-related protein complex 2, mu 1 subunit
Protein AP2M1 PDB 1bw8.png
PDB rendering based on 1bw8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols AP2M1 ; AP50; CLAPM1; mu2
External IDs OMIM601024 MGI1298405 HomoloGene3000 GeneCards: AP2M1 Gene
RNA expression pattern
PBB GE AP2M1 200613 at tn.png
More reference expression data
Species Human Mouse
Entrez 1173 11773
Ensembl ENSG00000161203 ENSMUSG00000022841
UniProt Q96CW1 P84091
RefSeq (mRNA) NM_001025205 NM_001302970
RefSeq (protein) NP_001020376 NP_001289899
Location (UCSC) Chr 3:
184.17 – 184.18 Mb
Chr 16:
20.54 – 20.54 Mb
PubMed search [1] [2]

AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.[1]


This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.[2]


AP2M1 has been shown to interact with CTLA-4[3][4] and Alpha-1B adrenergic receptor.[5]


  1. ^ Druck T, Gu Y, Prabhala G, Cannizzaro LA, Park SH, Huebner K, Keen JH (Nov 1995). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics 30 (1): 94–7. doi:10.1006/geno.1995.0016. PMID 8595912. 
  2. ^ "Entrez Gene: AP2M1 adaptor-related protein complex 2, mu 1 subunit". 
  3. ^ Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, Rowsell S, Stacey CL, Stanway JJ, Taylor IW, Abbott WM (Oct 2001). "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28". The Biochemical Journal 359 (Pt 2): 427–34. doi:10.1042/0264-6021:3590427. PMC 1222163. PMID 11583591. 
  4. ^ Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB (Jul 1997). "Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression". Journal of Immunology 159 (1): 144–51. PMID 9200449. 
  5. ^ Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S (May 2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". The Journal of Biological Chemistry 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451. 

Further reading[edit]