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Protein AP2M1 PDB 1bw8.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesAP2M1, AP50, CLAPM1, mu2, adaptor related protein complex 2 mu 1 subunit, adaptor related protein complex 2 subunit mu 1, MRD60
External IDsOMIM: 601024 MGI: 1298405 HomoloGene: 3000 GeneCards: AP2M1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for AP2M1
Genomic location for AP2M1
Band3q27.1Start184,174,689 bp[1]
End184,184,091 bp[1]
RNA expression pattern
PBB GE AP2M1 200613 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 184.17 – 184.18 MbChr 16: 20.54 – 20.54 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.[5]


This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.[6]


AP2M1 has been shown to interact with CTLA-4[7][8] and Alpha-1B adrenergic receptor.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161203 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022841 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Druck T, Gu Y, Prabhala G, Cannizzaro LA, Park SH, Huebner K, Keen JH (Nov 1995). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics. 30 (1): 94–7. doi:10.1006/geno.1995.0016. PMID 8595912.
  6. ^ "Entrez Gene: AP2M1 adaptor-related protein complex 2, mu 1 subunit".
  7. ^ Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, Rowsell S, Stacey CL, Stanway JJ, Taylor IW, Abbott WM (Oct 2001). "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28". The Biochemical Journal. 359 (Pt 2): 427–34. doi:10.1042/0264-6021:3590427. PMC 1222163. PMID 11583591.
  8. ^ Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB (Jul 1997). "Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression". Journal of Immunology. 159 (1): 144–51. PMID 9200449.
  9. ^ Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S (May 2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". The Journal of Biological Chemistry. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.

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