APPBP1

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NAE1
Protein APPBP1 PDB 1r4m.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NAE1, A-116A10.1, APPBP1, ula-1, HPP1, NEDD8 activating enzyme E1 subunit 1
External IDs MGI: 2384561 HomoloGene: 68370 GeneCards: 8883
RNA expression pattern
PBB GE APPBP1 202268 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001018159
NM_001018160
NM_001286500
NM_003905

NM_144931

RefSeq (protein)

NP_001018169.1
NP_001018170.1
NP_001273429.1
NP_003896.1

NP_659180.1

Location (UCSC) Chr 16: 66.8 – 66.87 Mb Chr 8: 104.51 – 104.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene.[1][2][3]

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.[3]

Interactions[edit]

APPBP1 has been shown to interact with UBE1C,[4] TRIP12[5] and Amyloid precursor protein.[1]

References[edit]

  1. ^ a b Chow N, Korenberg JR, Chen XN, Neve RL (June 1996). "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein". J Biol Chem 271 (19): 11339–46. doi:10.1074/jbc.271.19.11339. PMID 8626687. 
  2. ^ Bohnsack RN, Haas AL (July 2003). "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer". J Biol Chem 278 (29): 26823–30. doi:10.1074/jbc.M303177200. PMID 12740388. 
  3. ^ a b "Entrez Gene: APPBP1 amyloid beta precursor protein binding protein 1". 
  4. ^ Chen, Y; McPhie D L; Hirschberg J; Neve R L (March 2000). "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons". J. Biol. Chem. (UNITED STATES) 275 (12): 8929–35. doi:10.1074/jbc.275.12.8929. ISSN 0021-9258. PMID 10722740. 
  5. ^ Park, Yoon; Yoon Sungjoo Kim; Yoon Jong-Bok (September 2008). "TRIP12 functions as an E3 ubiquitin ligase of APP-BP1". Biochem. Biophys. Res. Commun. (United States) 374 (2): 294–8. doi:10.1016/j.bbrc.2008.07.019. PMID 18627766. 

Further reading[edit]