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NEDD8 activating enzyme E1 subunit 1
Protein APPBP1 PDB 1r4m.png
PDB rendering based on 1r4m.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NAE1 ; A-116A10.1; APPBP1; HPP1; ula-1
External IDs OMIM603385 MGI2384561 HomoloGene68370 GeneCards: NAE1 Gene
RNA expression pattern
PBB GE APPBP1 202268 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8883 234664
Ensembl ENSG00000159593 ENSMUSG00000031878
UniProt Q13564 Q8VBW6
RefSeq (mRNA) NM_001018159 NM_144931
RefSeq (protein) NP_001018169 NP_659180
Location (UCSC) Chr 16:
66.8 – 66.87 Mb
Chr 8:
104.51 – 104.53 Mb
PubMed search [1] [2]

NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene.[1][2][3]

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.[3]


APPBP1 has been shown to interact with UBE1C,[4] TRIP12[5] and Amyloid precursor protein.[1]


  1. ^ a b Chow N, Korenberg JR, Chen XN, Neve RL (June 1996). "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein". J Biol Chem 271 (19): 11339–46. doi:10.1074/jbc.271.19.11339. PMID 8626687. 
  2. ^ Bohnsack RN, Haas AL (July 2003). "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer". J Biol Chem 278 (29): 26823–30. doi:10.1074/jbc.M303177200. PMID 12740388. 
  3. ^ a b "Entrez Gene: APPBP1 amyloid beta precursor protein binding protein 1". 
  4. ^ Chen, Y; McPhie D L; Hirschberg J; Neve R L (March 2000). "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons". J. Biol. Chem. (UNITED STATES) 275 (12): 8929–35. doi:10.1074/jbc.275.12.8929. ISSN 0021-9258. PMID 10722740. 
  5. ^ Park, Yoon; Yoon Sungjoo Kim; Yoon Jong-Bok (September 2008). "TRIP12 functions as an E3 ubiquitin ligase of APP-BP1". Biochem. Biophys. Res. Commun. (United States) 374 (2): 294–8. doi:10.1016/j.bbrc.2008.07.019. PMID 18627766. 

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