UBE1C

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
UBA3
Protein UBE1C PDB 1r4m.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBA3, NAE2, UBE1C, hubiquitin like modifier activating enzyme 3
External IDsMGI: 1341217 HomoloGene: 2951 GeneCards: UBA3
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for UBA3
Genomic location for UBA3
Band3p14.1Start69,054,730 bp[1]
End69,080,408 bp[1]
RNA expression pattern
PBB GE UBE1C 209115 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003968
NM_198195
NM_198197
NM_001363861

NM_001111106
NM_001301857
NM_001301858
NM_001301859
NM_011666

RefSeq (protein)

NP_003959
NP_937838
NP_001350790

NP_001104576
NP_001288786
NP_001288787
NP_001288788
NP_035796

Location (UCSC)Chr 3: 69.05 – 69.08 MbChr 6: 97.18 – 97.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
E2 binding domain
PDB 1r4n EBI.jpg
appbp1-uba3-nedd8, an e1-ubiquitin-like protein complex with atp
Identifiers
SymbolE2_bind
PfamPF08825
InterProIPR014929

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

This enzyme contains an E2 binding domain, which resembles ubiquitin, and recruits the catalytic core of the E2 enzyme UBE2M (Ubc12) in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.[7]

Interactions[edit]

UBE1C has been shown to interact with NEDD8,[8] APPBP1[9] and UBE2M.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144744 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030061 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, Kawashima S, Tanaka K, Kato S (August 1998). "A new NEDD8-ligating system for cullin-4A". Genes Dev. 12 (15): 2263–8. doi:10.1101/gad.12.15.2263. PMC 317039. PMID 9694792.
  6. ^ a b "Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)".
  7. ^ a b Huang DT, Paydar A, Zhuang M, Waddell MB, Holton JM, Schulman BA (February 2005). "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1". Mol. Cell. 17 (3): 341–50. doi:10.1016/j.molcel.2004.12.020. PMID 15694336.
  8. ^ Gong, L; Yeh E T (April 1999). "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway". J. Biol. Chem. UNITED STATES. 274 (17): 12036–42. doi:10.1074/jbc.274.17.12036. ISSN 0021-9258. PMID 10207026.
  9. ^ Chen, Y; McPhie D L; Hirschberg J; Neve R L (March 2000). "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons". J. Biol. Chem. UNITED STATES. 275 (12): 8929–35. doi:10.1074/jbc.275.12.8929. ISSN 0021-9258. PMID 10722740.

Further reading[edit]


This article incorporates text from the public domain Pfam and InterPro: IPR014929