UBE1C

From Wikipedia, the free encyclopedia
Jump to: navigation, search
UBA3
Protein UBE1C PDB 1r4m.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UBA3, NAE2, UBE1C, hubiquitin like modifier activating enzyme 3
External IDs MGI: 1341217 HomoloGene: 2951 GeneCards: 9039
RNA expression pattern
PBB GE UBE1C 209115 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003968
NM_198195
NM_198197

NM_001111106
NM_001301857
NM_001301858
NM_001301859
NM_011666

RefSeq (protein)

NP_003959.3
NP_937838.1

NP_001104576.1
NP_001288786.1
NP_001288787.1
NP_001288788.1
NP_035796.2

Location (UCSC) Chr 3: 69.05 – 69.08 Mb Chr 6: 97.18 – 97.21 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse
E2 binding domain
PDB 1r4n EBI.jpg
appbp1-uba3-nedd8, an e1-ubiquitin-like protein complex with atp
Identifiers
Symbol E2_bind
Pfam PF08825
InterPro IPR014929

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.[3][4]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[4]

This enzyme contains an E2 binding domain, which resembles ubiquitin, and recruits the catalytic core of the E2 enzyme UBE2M (Ubc12) in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.[5]

Interactions[edit]

UBE1C has been shown to interact with NEDD8,[6] APPBP1[7] and UBE2M.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, Kawashima S, Tanaka K, Kato S (August 1998). "A new NEDD8-ligating system for cullin-4A". Genes Dev. 12 (15): 2263–8. doi:10.1101/gad.12.15.2263. PMC 317039free to read. PMID 9694792. 
  4. ^ a b "Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)". 
  5. ^ a b Huang DT, Paydar A, Zhuang M, Waddell MB, Holton JM, Schulman BA (February 2005). "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1". Mol. Cell. 17 (3): 341–50. doi:10.1016/j.molcel.2004.12.020. PMID 15694336. 
  6. ^ Gong, L; Yeh E T (April 1999). "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway". J. Biol. Chem. UNITED STATES. 274 (17): 12036–42. doi:10.1074/jbc.274.17.12036. ISSN 0021-9258. PMID 10207026. 
  7. ^ Chen, Y; McPhie D L; Hirschberg J; Neve R L (March 2000). "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons". J. Biol. Chem. UNITED STATES. 275 (12): 8929–35. doi:10.1074/jbc.275.12.8929. ISSN 0021-9258. PMID 10722740. 

Further reading[edit]


This article incorporates text from the public domain Pfam and InterPro IPR014929