Aconitate decarboxylase

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aconitate decarboxylase
Identifiers
EC number 4.1.1.6
CAS number 9025-01-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, an aconitate decarboxylase (EC 4.1.1.6) is an enzyme that catalyzes the chemical reaction

cis-aconitate itaconate + CO2

Hence, this enzyme has one substrate, cis-aconitate, and two products, itaconate and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is cis-aconitate carboxy-lyase (itaconate-forming). Other names in common use include cis-aconitic decarboxylase, CAD, cis-aconitate carboxy-lyase, and cis-aconitate carboxy-lyase. This enzyme participates in c5-branched dibasic acid metabolism.

References[edit]

  • BENTLEY R, THIESSEN CP (1957). "Biosynthesis of itaconic acid in Aspergillus terreus. III. The properties and reaction mechanism of cis-aconitic acid decarboxylase". J. Biol. Chem. 226 (2): 703–20. PMID 13438855.