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Arylmalonate decarboxylase

From Wikipedia, the free encyclopedia
arylmalonate decarboxylase
Identifiers
EC no.4.1.1.76
CAS no.144713-36-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme arylmalonate decarboxylase (EC 4.1.1.76) catalyzes the chemical reaction

2-aryl-2-methylmalonate 2-arylpropanoate + CO2

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming). Other names in common use include AMDASE, 2-aryl-2-methylmalonate carboxy-lyase, and 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropionate-forming).

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2DGD.

References

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  • Miyamoto K, Ohta H (1992). "Cloning and heterologous expression of a novel arylmalonate decarboxylase gene from Alcaligenes bronchisepticus KU 1201". Appl. Microbiol. Biotechnol. 38 (2): 234–8. doi:10.1007/bf00174474. PMID 1369144. S2CID 11058932.