BRD7
Appearance
Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.[5][6][7]
Interactions
BRD7 has been shown to interact with IRF2[8] and HNRPUL1.[9]
BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced.[10] Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.[10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000166164 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031660 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cuppen E, van Ham M, Pepers B, Wieringa B, Hendriks W (November 1999). "Identification and molecular characterization of BP75, a novel bromodomain-containing protein". FEBS Lett. 459 (3): 291–298. doi:10.1016/S0014-5793(99)01191-6. PMID 10526152.
- ^ Kaeser MD, Aslanian A, Dong MQ, Yates JR III, Emerson BM (November 2008). "BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells". J Biol Chem. 283 (47): 32254–32263. doi:10.1074/jbc.M806061200. PMC 2583284. PMID 18809673.
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: CS1 maint: unflagged free DOI (link) - ^ "Entrez Gene: BRD7 bromodomain containing 7".
- ^ Staal, A; Enserink J M; Stein J L; Stein G S; van Wijnen A J (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2). UNITED STATES: 269–279. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. ISSN 0021-9541. PMID 11025449.
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(help) - ^ Kzhyshkowska, Julia; Rusch Andre; Wolf Hans; Dobner Thomas (April 2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. 371 (Pt 2). England: 385–93. doi:10.1042/BJ20021281. ISSN 0264-6021. PMC 1223277. PMID 12489984.
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(help) - ^ a b Wang H, Zhao R, Guo C, Jiang S, Yang J, Xu Y, Liu Y, Fan L, Xiong W, Ma J, Peng S, Zeng Z, Zhou Y, Li X, Li Z, Li X, Schmitt DC, Tan M, Li G, Zhou M (2016). "Knockout of BRD7 results in impaired spermatogenesis and male infertility". Sci Rep. 6: 21776. Bibcode:2016NatSR...621776W. doi:10.1038/srep21776. PMC 4754950. PMID 26878912.
External links
- Human BRD7 genome location and BRD7 gene details page in the UCSC Genome Browser.