BRMS1

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BRMS1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BRMS1, breast cancer metastasis suppressor 1
External IDs MGI: 2388804 HomoloGene: 32260 GeneCards: BRMS1
RNA expression pattern
PBB GE BRMS1 215631 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015399
NM_001024957
NM_001024958

NM_134155

RefSeq (protein)

NP_001020128
NP_056214

NP_598916.1
NP_598916

Location (UCSC) Chr 11: 66.34 – 66.35 Mb Chr 19: 5.04 – 5.05 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Breast cancer metastasis-suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.[3][4]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[5] The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Res. 60 (11): 2764–9. PMID 10850410. 
  4. ^ a b "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1". 
  5. ^ Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

External links[edit]

Further reading[edit]