BRMS1

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BRMS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRMS1, breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator
External IDsMGI: 2388804 HomoloGene: 32260 GeneCards: BRMS1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for BRMS1
Genomic location for BRMS1
Band11q13.2Start66,337,333 bp[1]
End66,345,125 bp[1]
RNA expression pattern
PBB GE BRMS1 215631 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015399
NM_001024957
NM_001024958

NM_134155

RefSeq (protein)

NP_001020128
NP_056214

NP_598916

Location (UCSC)Chr 11: 66.34 – 66.35 MbChr 19: 5.04 – 5.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Breast cancer metastasis-suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.[5][6]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[7] The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174744 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000080268 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Res. 60 (11): 2764–9. PMID 10850410.
  6. ^ a b "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
  7. ^ Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

External links[edit]

Further reading[edit]