Basophilia
 | This article may need to be rewritten to comply with Wikipedia's quality standards. (November 2016) |
 | This article needs additional citations for verification. (November 2016) |
| Basophilia | |
|---|---|
| Specialty | Hematology  |
Basophilia is a condition where the basophil quantity is abnormally elevated (more than 1010 basophils per liter of blood).[1] Basophilia is associated with pruritus (itching) due to the basophils release of histamine.[2]
Causes
Basophilia as an isolated finding is uncommon. However it is a common feature of myeloproliferative disorders and particularly prominent in chronic myelogenous leukemia.[3][4]
Conditions Associated with Alterations in Numbers of Blood Basophils
I. Decreased Numbers (Basopenia)
A. Hereditary absence of basophils (very rare) B. Elevated levels of glucocorticoids C. Hyperthyroidism or treatment with thyroid hormones D. Ovulation E. Hypersensitivity reactions 1. Urticaria 2. Anaphylaxis 3. Drug-induced reactions F. Leukocytosis (in association with diverse disorders)
II. Increased Numbers (Basophilia)
A. Allergy or inflammation 1. Ulcerative colitis 2. Drug, food, inhalant hypersensitivity 3. Erythroderma, urticaria 4. Juvenile rheumatoid arthritis B. Endocrinopathy 1. Diabetes mellitus 2. Estrogen administration 3. Hypothyroidism (myxedema) C. Infection 1. Chicken pox 2. Influenza 3. Smallpox 4. Tuberculosis D. Iron deficiency E. Exposure to ionizing radiation F. Neoplasia 1. "Basophilic leukemia" (see text) G. Myeloproliferative neoplasms (especially chronic myelogenous leukemia; also polycythemia vera, primary myelofibrosis, essential thrombocythemia) H. Carcinoma
References
- ^ "Cytoplasmic basophilia". Veterinary Clinical Pathology Image Database. University of Montreal Veterinary College. Retrieved 2008-09-20.
- ^ Interactive, Wellfire. "Pathology Thread". www.med-ed.virginia.edu. Retrieved 2016-04-07.
- ^ Ravandi, F.; R. Hoffman (2005). "Chapter 17. Phagocytes". In A.V. Hoffbrand; et al. (eds.). Postgraduate Haematology. Boston: Blackwell Publishing. pp. 296–298. ISBN 1-4051-0821-5.
- ^ Table 12-6 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
 | This article about a disease of the blood or immune system is a stub. You can help Wikipedia by expanding it. |