Cyclic neutropenia

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Cyclic neutropenia (or cyclical neutropenia) is a form of neutropenia that tends to occur every three weeks and lasting three to six days at a time due to changing rates of cell production by the bone marrow.[1]

It is often present among several members of the same family. Treatment includes G-CSF and usually improves after puberty.

Cyclic neutropenia is the result of autosomal dominantly inherited mutations in ELA2, the gene encoding neutrophil elastase.[2]

See also[edit]

May be associated with oral cankers, canker sores or lesions. McBride DR (July 2000). "Management of aphthous ulcers". Am Fam Physician. 62 (1): 149–54, 160. PMID 10905785. 


  1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. p. 811. ISBN 0-7216-2921-0. 
  2. ^ Sera Y, Kawaguchi H, Nakamura K; et al. (2005). "A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia". Haematologica. 90 (8): 1032–41. PMID 16079102. 

External links[edit]

External resources