CDC42EP2

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CDC42EP2
Identifiers
Aliases CDC42EP2, BORG1, CEP2, CDC42 effector protein 2
External IDs MGI: 1929744 HomoloGene: 4933 GeneCards: CDC42EP2
RNA expression pattern
PBB GE CDC42EP2 209850 s at fs.png

PBB GE CDC42EP2 214014 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006779

NM_026772

RefSeq (protein)

NP_006770

NP_081048.1
NP_081048

Location (UCSC) Chr 11: 65.31 – 65.32 Mb Chr 19: 5.92 – 5.92 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.[3][4][5]

Function[edit]

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.[5]

Interactions[edit]

CDC42EP2 has been shown to interact with CDC42[3][4] and RHOQ.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c Joberty G, Perlungher RR, Macara IG (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Molecular and Cellular Biology. 19 (10): 6585–97. PMC 84628Freely accessible. PMID 10490598. 
  4. ^ a b Hirsch DS, Pirone DM, Burbelo PD (Jan 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". The Journal of Biological Chemistry. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016. 
  5. ^ a b "Entrez Gene: CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2". 

External links[edit]

Further reading[edit]