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COG7

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COG7
Identifiers
AliasesCOG7, CDG2E, component of oligomeric golgi complex 7
External IDsOMIM: 606978; MGI: 2685013; HomoloGene: 33431; GeneCards: COG7; OMA:COG7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153603

NM_001033318

RefSeq (protein)

NP_705831

NP_001028490

Location (UCSC)Chr 16: 23.39 – 23.45 MbChr 7: 121.48 – 121.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.[5][6]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002).[supplied by OMIM][6]

Interactions

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COG7 has been shown to interact with COG4[7] and COG5.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168434Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034951Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  6. ^ a b "Entrez Gene: COG7 component of oligomeric golgi complex 7".
  7. ^ a b Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.

Further reading

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