CTNND1

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Catenin (cadherin-associated protein), delta 1
Protein CTNND1 PDB 3L6X.png
Rendering based on PDB 3L6X.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CTNND1 ; CAS; CTNND; P120CAS; P120CTN; p120; p120(CAS); p120(CTN)
External IDs OMIM601045 MGI105100 HomoloGene1017 GeneCards: CTNND1 Gene
Orthologs
Species Human Mouse
Entrez 1500 12388
Ensembl ENSG00000198561 ENSMUSG00000034101
UniProt O60716 P30999
RefSeq (mRNA) NM_001085458 NM_001085448
RefSeq (protein) NP_001078927 NP_001078917
Location (UCSC) Chr 11:
57.52 – 57.59 Mb
Chr 2:
84.6 – 84.65 Mb
PubMed search [1] [2]

Catenin delta-1 is a protein that in humans is encoded by the CTNND1 gene.[1]

Function[edit]

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.[2]

Interactions[edit]

CTNND1 has been shown to interact with:

See also[edit]


References[edit]

  1. ^ Reynolds A, Jenkins N, Gilbert D, Copeland N, Shapiro D, Wu J et al. (October 1996). "The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)". Genomics 31 (1): 127–9. doi:10.1006/geno.1996.0020. PMID 8808291. 
  2. ^ "Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1". 
  3. ^ a b Hazan R, Norton L. "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. PMID 9535896. 
  4. ^ Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V. "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. 8 (6): 695–8. PMID 11712088. 
  5. ^ a b c Piedra J, Miravet S, Castaño J, Pálmer H, Heisterkamp N, García de Herreros A et al. "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7): 2287–97. PMC 150740. PMID 12640114. 
  6. ^ Daniel J, Reynolds A. "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. PMC 230726. PMID 7651399. 
  7. ^ Ireton R, Davis M, van Hengel J, Mariner D, Barnes K, Thoreson M et al. "A novel role for p120 catenin in E-cadherin function". J. Cell Biol. 159 (3): 465–76. doi:10.1083/jcb.200205115. PMC 2173073. PMID 12427869. 
  8. ^ Kinch M, Clark G, Der C, Burridge K. "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. PMC 2199929. PMID 7542250. 
  9. ^ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green K, van Roy F. "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304. 
  10. ^ Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N et al. "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. PMC 2120395. PMID 7876318. 
  11. ^ Ohkubo T, Ozawa M. "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. PMID 10409703. 
  12. ^ Straub B, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T et al. "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392. 
  13. ^ Wahl J, Kim Y, Cullen J, Johnson K, Wheelock M. "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. 278 (19): 17269–76. doi:10.1074/jbc.M211452200. PMID 12604612. 
  14. ^ Aho S, Rothenberger K, Uitto J. "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. PMID 10321838. 
  15. ^ a b Martinez M, Ochiishi T, Majewski M, Kosik K. "Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho". J. Cell Biol. 162 (1): 99–111. doi:10.1083/jcb.200211025. PMC 2172717. PMID 12835311. 
  16. ^ Li Y, Kufe D. "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. 281 (2): 440–3. doi:10.1006/bbrc.2001.4383. PMID 11181067. 
  17. ^ Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar M. "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol. 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. PMC 1618613. PMID 15331416. 
  18. ^ Tanahashi H, Tabira T. "Isolation of human delta-catenin and its binding specificity with presenilin 1". Neuroreport 10 (3): 563–8. PMID 10208590. 
  19. ^ Keilhack H, Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Böhmer F. "The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin". J. Biol. Chem. 275 (34): 26376–84. doi:10.1074/jbc.M001315200. PMID 10835420. 
  20. ^ Holsinger L, Ward K, Duffield B, Zachwieja J, Jallal B. "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene 21 (46): 7067–76. doi:10.1038/sj.onc.1205858. PMID 12370829. 
  21. ^ Zondag G, Reynolds A, Moolenaar W. "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)". J. Biol. Chem. 275 (15): 11264–9. PMID 10753936. 
  22. ^ Ferber A, Yaen C, Sarmiento E, Martinez J. "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44. doi:10.1006/excr.2001.5436. PMID 11855855. 
  23. ^ Lampugnani M, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E. "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell. Sci. 110 ( Pt 17): 2065–77. PMID 9378757. 
  24. ^ Daniel J, Reynolds A. "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Mol. Cell. Biol. 19 (5): 3614–23. PMC 84161. PMID 10207085. 

Further reading[edit]