Invasive lobular carcinoma demonstrating a predominantly lobular growth pattern.
Lobular breast cancer. Single file cells and cell nests.
Histopathologic types of breast cancer, with relative incidences and prognoses, with "invasive lobular carcinoma" at top right.
Invasive lobular carcinoma is breast cancer arising from the lobules of the mammary glands. It accounts for 5-10% of invasive  breast cancer. 
The histologic patterns include:
round or ovoid cells with little cytoplasm in a single-file infiltrating pattern, sometimes concentrically giving a
No dominant pattern
Sheets of classical-appearing cells with little intervening stroma
Aggregates of classical-appearing cells
Cells form microtubules in >90% of tumor (smaller than in tubular carcinoma)
Classical-appearing but with pleomorphic cells
Overall, the five-year survival rate of invasive lobular carcinoma was approximately 85% in 2003.
E-cadherin is common in lobular carcinoma but is also seen in other breast cancers.
Treatment includes surgery and adjuvant therapy.
References [ edit ]
"Breast Cancer Treatment (PDQ®)". NCI. 23 May 2014. Archived from the original on 5 July 2014 . Retrieved . 29 June 2014
Pointon KS, Cunningham DA (August 1999). "Ultrasound findings in pure invasive lobular carcinoma of the breast: comparison with matched cases of invasive ductal carcinoma of the breast". Breast. 8 (4): 188–90. doi: 10.1054/brst.1999.0042. PMID 14731438.
Boughey JC, Wagner J, Garrett BJ, et al. (March 2009). "Neoadjuvant Chemotherapy in Invasive Lobular Carcinoma May Not Improve Rates of Breast Conservation". Ann. Surg. Oncol. 16 (6): 1606–11. doi: 10.1245/s10434-009-0402-z. PMC . 4338983 PMID 19280264.
Moore MM, Borossa G, Imbrie JZ, et al. (June 2000). "Association of Infiltrating Lobular Carcinoma With Positive Surgical Margins After Breast-Conservation Therapy". Ann. Surg. 231 (6): 877–82. doi: 10.1097/00000658-200006000-00012. PMC . 1421077 PMID 10816631.
Spencer JT, Shutter J (March 2009). "Synchronous bilateral invasive lobular breast cancer presenting as carcinomatosis in a male". Am. J. Surg. Pathol. 33 (3): 470–4. doi: 10.1097/PAS.0b013e318190d10d. PMID 19092630.
^ Fletcher's diagnostic histopathology of tumors. 3rd Ed. p. 931-932.
Arpino G, Bardou VJ, Clark GM, Elledge RM (2004). "Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome". Breast Cancer Res. 6 (3): R149–56. doi: 10.1186/bcr767. PMC . 400666 PMID 15084238.
Varga Z, Mallon E (Oct 2009). "Histology and Immunophenotype of Invasive Lobular Breast Cancer. Daily Practice and Pitfalls" (PDF). Breast Dis. 30: 15–19. doi: 10.3233/BD-2009-0278. PMID 19850991.
External links [ edit ]