Calumenin

CALU
Identifiers
Aliases	CALU, calumenin
External IDs	OMIM: 603420; MGI: 1097158; HomoloGene: 936; GeneCards: CALU; OMA:CALU - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,773,400 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	29,377,109 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; smooth muscle tissue; ; tendon of biceps brachii; ; thoracic aorta; ; ascending aorta; ; right coronary artery; ; Achilles tendon; ; Descending thoracic aorta; ; left coronary artery; ; popliteal artery;
	Top expressed in
	gastrula; ; calvaria; ; dermis; ; efferent ductule; ; molar; ; stroma of bone marrow; ; umbilical cord; ; body of femur; ; atrium; ; Gonadal ridge;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; protein binding;
Cellular component	Golgi apparatus; endoplasmic reticulum membrane; membrane; melanosome; sarcoplasmic reticulum; extracellular region; endoplasmic reticulum; sarcoplasmic reticulum lumen; endoplasmic reticulum lumen;
Biological process	post-translational protein modification; biological process;
	Sources:Amigo / QuickGO
Orthologs
	813
	12321
	ENSG00000128595
	ENSMUSG00000029767
	O43852
	O35887
NM_001130674; NM_001199671; NM_001199672; NM_001199673; NM_001199674;
	NM_001219
	NM_001285412; NM_007594; NM_184053
	NP_001124146; NP_001186600; NP_001186601; NP_001186602; NP_001210
	NP_001272341; NP_031620; NP_908942
	Wikidata
View/Edit Human	View/Edit Mouse

Calumenin is a protein that in humans is encoded by the CALU gene.^[5]^[6]

Calumenin (CALU) is a calcium-binding protein localized in the endoplasmic reticulum (ER) and is involved in such ER functions as protein folding and sorting. Calumenin is a member of the EF-hand superfamily in the ER and Golgi apparatus named CERC. CERC is an acronym for its family members Cab-45, reticulocalbin, Erc-55 (RCN2), and calumenin. The CALU gene encodes a deduced 315-amino acid protein containing 6 EF-hand motifs, 1 potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse CALU proteins are 98% identical. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128595 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029767 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yabe D, Taniwaki M, Nakamura T, Kanazawa N, Tashiro K, Honjo T (Aug 1998). "Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32". Genomics. 49 (2): 331–3. doi:10.1006/geno.1998.5245. PMID 9598325.
^ ^a ^b "Entrez Gene: CALU calumenin".

External links

Human CALU genome location and CALU gene details page in the UCSC Genome Browser.

References

External links

Further reading