Citramalate lyase

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citramalate lyase
EC no.
CAS no.9027-93-4
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a citramalate lyase (EC is an enzyme that catalyzes the chemical reaction

(2S)-2-hydroxy-2-methylbutanedioate acetate + pyruvate

Hence, this enzyme has one substrate, (2S)-2-hydroxy-2-methylbutanedioate, and two products, acetate and pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase (acetate-forming). Other names in common use include citramalate pyruvate-lyase, citramalate synthase, citramalic-condensing enzyme, citramalate synthetase, citramalic synthase, (S)-citramalate lyase, (+)-citramalate pyruvate-lyase, citramalate pyruvate lyase, (3S)-citramalate pyruvate-lyase, and (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase. This enzyme participates in c5-branched dibasic acid metabolism.


  • Barker HA (1967). "Citramalate lyase of Clostridium tetanomorphum". Arch. Mikrobiol. 59 (1): 4–12. doi:10.1007/BF00406311. PMID 4301387.
  • Dimroth P, Buckel W, Loyal R, Eggerer H (1977). "Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase". Eur. J. Biochem. 80 (2): 469–77. doi:10.1111/j.1432-1033.1977.tb11902.x. PMID 923590.