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Clinical data
AHFS/ International Drug Names
ATC code
CAS Number
PubChem CID
Chemical and physical data
Formula C205H339N59O63S
Molar mass 4670.31 g/mol

Corticorelin (INN) is a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH).[1]

The corticorelin stimulation test helps to differentiate between the etiologies of adrenocorticotropic hormone (ACTH)-dependent hypercortisolism. It is used to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.

  • If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of Cushing's disease is achieved (ACTH of pituitary origin).
  • If corticorelin injection leads to little or no response in plasma levels of ACTH or cortisol, a diagnosis of ectopic ACTH syndrome is confirmed.

See also[edit]


  1. ^ Andoh K, Kimura T, Saeki I, et al. (June 1994). "General pharmacological properties of the human corticotropin-releasing hormone corticorelin (human)". Arzneimittelforschung. 44 (6): 715–26. PMID 8053970.