Corticorelin ( INN) is a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH). 
The corticorelin stimulation test helps to differentiate between the etiologies of
adrenocorticotropic hormone (ACTH)-dependent hypercortisolism. It is used to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.
If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of
Cushing's disease is achieved (ACTH of pituitary origin). If corticorelin injection leads to little or no response in plasma levels of ACTH or cortisol, a diagnosis of
ectopic ACTH syndrome is confirmed.
See also [ edit ]
References [ edit ]
^ Andoh K, Kimura T, Saeki I, et al. (June 1994). "General pharmacological properties of the human corticotropin-releasing hormone corticorelin (human)". Arzneimittelforschung. 44 (6): 715–26. PMID 8053970.