Corticorelin

Corticorelin
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	V04CD04 (WHO) ;
Identifiers
CAS Number	79804-71-0;
PubChem CID	16132344;
UNII	305OE8862Y;
CompTox Dashboard (EPA)	DTXSID90229925 ;
Chemical and physical data
Formula	C205H339N59O63S
Molar mass	4670.31 g/mol g·mol−1
	(verify)

Corticorelin (INN) is a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH).^[1]

The corticorelin stimulation test helps to differentiate between the etiologies of adrenocorticotropic hormone (ACTH)-dependent hypercortisolism. It is used to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.

If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of Cushing's disease is achieved (ACTH of pituitary origin).
If corticorelin injection leads to little or no response in plasma levels of ACTH or cortisol, a diagnosis of ectopic ACTH syndrome is confirmed.

References

^ Andoh K, Kimura T, Saeki I, et al. (June 1994). "General pharmacological properties of the human corticotropin-releasing hormone corticorelin (human)". Arzneimittelforschung. 44 (6): 715–26. PMID 8053970.

Template:Neuropeptidergics

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

[pmid8053970-1] Andoh K, Kimura T, Saeki I, et al. (June 1994). "General pharmacological properties of the human corticotropin-releasing hormone corticorelin (human)". Arzneimittelforschung. 44 (6): 715–26. PMID 8053970.

[1]

See also

References