DDX6

DDX6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1VEC, 2WAX, 2WAY, 4CRW, 4CT4, 4CT5, 5ANR
Identifiers
Aliases	DDX6, HLR2, P54, RCK, DEAD-box helicase 6, IDDILF, Rck/p54
External IDs	OMIM: 600326; MGI: 104976; HomoloGene: 3238; GeneCards: DDX6; OMA:DDX6 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,791,164 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,552,028 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; ventricular zone; ; middle temporal gyrus; ; superior vestibular nucleus; ; amniotic fluid; ; internal globus pallidus; ; vena cava; ; lateral nuclear group of thalamus; ; trigeminal ganglion;
	Top expressed in
	aortic valve; ; ascending aorta; ; gastrula; ; saccule; ; otic placode; ; supraoptic nucleus; ; mesenteric lymph nodes; ; otic vesicle; ; lacrimal gland; ; superior cervical ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA helicase activity; nucleotide binding; helicase activity; protein domain specific binding; protein binding; nucleic acid binding; hydrolase activity; ATP binding; RNA binding; cadherin binding;
Cellular component	cytoplasm; RISC complex; membrane; P-body; cytoplasmic stress granule; mitochondrion; sperm annulus; P granule; outer dense fiber; heterochromatin; nucleus; cytosol; nucleolus; cytoplasmic ribonucleoprotein granule; chromatoid body; perinuclear region of cytoplasm; concave side of sperm head;
Biological process	negative regulation of neuron differentiation; stem cell population maintenance; RNA secondary structure unwinding; P-body assembly; exonucleolytic catabolism of deadenylated mRNA; viral RNA genome packaging; regulation of translation; spermatogenesis; spermatid differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1656
	13209
	ENSG00000110367
	ENSMUSG00000032097
	P26196
	P54823
	NM_001257191; NM_004397
	NM_001110826; NM_007841; NM_181324; NM_001357702; NM_001357703
	NP_001244120; NP_004388
	NP_001104296; NP_031867; NP_851841; NP_001344631; NP_001344632
	Wikidata
View/Edit Human	View/Edit Mouse

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110367 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032097 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lu D, Yunis JJ (Jun 1992). "Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3". Nucleic Acids Res. 20 (8): 1967–72. doi:10.1093/nar/20.8.1967. PMC 312313. PMID 1579499.
^ "Entrez Gene: DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6".

References

Further reading