DYX1C1

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DNAAF4
Identifiers
Aliases DNAAF4, CILD25, DYX1, DYXC1, EKN1, RD, DYX1C1, dyslexia susceptibility 1 candidate 1, dynein axonemal assembly factor 4
External IDs MGI: 1914935 HomoloGene: 12173 GeneCards: DNAAF4
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_130810
NM_001033559
NM_001033560

NM_001163725
NM_026314

RefSeq (protein)

NP_001028731
NP_001028732
NP_570722

NP_001157197
NP_080590

Location (UCSC) Chr 15: 55.41 – 55.51 Mb Chr 9: 72.96 – 72.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dyslexia susceptibility 1 candidate gene 1 protein is a protein that in humans is encoded by the DYX1C1 gene.[3][4] This protein contains 420-amino acids with 3 tetratricopeptide repeat (TPR) domains, thought to mediate protein–protein interactions.

Clinical significance[edit]

A mutation in the DYX1C1 gene has been associated with deficits in reading ability (dyslexia).[3][5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Taipale M, Kaminen N, Nopola-Hemmi J, Haltia T, Myllyluoma B, Lyytinen H, Muller K, Kaaranen M, Lindsberg PJ, Hannula-Jouppi K, Kere J (Oct 2003). "A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain". Proc Natl Acad Sci U S A. 100 (20): 11553–8. PMC 208796Freely accessible. PMID 12954984. doi:10.1073/pnas.1833911100. 
  4. ^ "Entrez Gene: DYX1C1 dyslexia susceptibility 1 candidate 1". 
  5. ^ Bates TC, Lind PA, Luciano M, Montgomery GW, Martin NG, Wright MJ (November 2009). "Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation". Mol. Psychiatry. 15 (12): 1190–6. PMID 19901951. doi:10.1038/mp.2009.120. 

Further reading[edit]