Diferric-transferrin reductase

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diferric-transferrin reductase
EC no.
CAS no.105238-49-1
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a diferric-transferrin reductase (EC is an enzyme that catalyzes the chemical reaction

transferrin[Fe(II)]2 + NAD+ + H+ transferrin[Fe(III)]2 + NADH

The 3 substrates of this enzyme are [[transferrin[Fe(II)]2]], NAD+, and H+, whereas its two products are [[transferrin[Fe(III)]2]] and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is transferrin[Fe(II)]2:NAD+ oxidoreductase. Other names in common use include diferric transferrin reductase, NADH diferric transferrin reductase, and transferrin reductase. This enzyme participates in porphyrin and chlorophyll metabolism.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1L5T.


  • Low H, Sun IL, Navas P, Grebing C, Crane FL, Morre DJ (1986). "Transplasmalemma electron transport from cells is part of a diferric transferrin reductase system". Biochem. Biophys. Res. Commun. 139 (3): 1117–23. doi:10.1016/S0006-291X(86)80293-5. PMID 3767994.