Dimethylamine-corrinoid protein Co-methyltransferase
| Dimethylamine-corrinoid protein Co-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.249 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Dimethylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.249, mtbB (gene), dimethylamine methyltransferase) is an enzyme with systematic name dimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- dimethylamine + [Co(I) dimethylamine-specific corrinoid protein] [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
This enzyme is involved in methanogenesis from dimethylamine.
References
- ^ Wassenaar, R.W.; Keltjens, J.T.; van der Drift, C.; Vogels, G.D. (1998). "Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro". Eur. J. Biochem. 253: 692–697. doi:10.1046/j.1432-1327.1998.2530692.x. PMID 9654067.
- ^ Ferguson, D.J. Jr.; Gorlatova, N.; Grahame, D.A.; Krzycki, J.A. (2000). "Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". J. Biol. Chem. 275: 29053–29060. doi:10.1074/jbc.m910218199. PMID 10852929.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Krzycki, J.A. (2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Curr. Opin. Chem. Biol. 8: 484–491. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490.
External links
- Dimethylamine---corrinoid+protein+Co-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)