Epstein–Barr virus nuclear antigen 3

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The Epstein–Barr virus nuclear antigen 3 (EBNA-3) is a family of viral proteins associated with the Epstein–Barr virus.[citation needed]

These genes also bind the host RBP-Jκ protein.[clarification needed][citation needed]

EBNA-3C can recruit[clarification needed] a ubiquitin ligase and has been shown to target cell-cycle regulators such as retinoblastoma protein (pRb).[1][2]


  1. ^ Knight JS, Sharma N, Robertson ES (2005). "SCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigen". Mol. Cell. Biol. 25 (5): 1749–63. doi:10.1128/MCB.25.5.1749-1763.2005. PMC 549383. PMID 15713632.
  2. ^ Knight JS, Sharma N, Robertson ES (2005). "Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18562–6. doi:10.1073/pnas.0503886102. PMC 1317900. PMID 16352731.