From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Protein RBPJ PDB 2f8x.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesRBPJ, AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region
External IDsMGI: 96522 HomoloGene: 7511 GeneCards: RBPJ
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for RBPJ
Genomic location for RBPJ
Band4p15.2Start26,163,455 bp[1]
End26,435,131 bp[1]
RNA expression pattern
PBB GE RBPJ 211974 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 4: 26.16 – 26.44 MbChr 5: 53.47 – 53.66 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Recombining binding protein suppressor of hairless is a protein that in humans is encoded by the RBPJ gene.[5][6][7]

RBPJ[8] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.[9]


RBPJ has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168214 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039191 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Amakawa R, Jing W, Ozawa K, Matsunami N, Hamaguchi Y, Matsuda F, Kawaichi M, Honjo T (Aug 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics. 17 (2): 306–15. doi:10.1006/geno.1993.1326. PMID 8406481.
  6. ^ Tang X, Saito-Ohara F, Song J, Koga C, Ugai H, Murakami H, Ikeuchi T, Yokoyama KK (Jun 1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". The Japanese Journal of Human Genetics. 42 (2): 337–41. doi:10.1007/BF02766956. PMID 9290259.
  7. ^ "Entrez Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region".
  8. ^ "Human Genome Organization: RBPJ Report".
  9. ^ Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD (Mar 1996). "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2". Molecular and Cellular Biology. 16 (3): 952–9. doi:10.1128/mcb.16.3.952. PMC 231077. PMID 8622698.
  10. ^ Nam Y, Weng AP, Aster JC, Blacklow SC (Jun 2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". The Journal of Biological Chemistry. 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465.
  11. ^ Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (Apr 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–43. doi:10.1074/jbc.272.17.11336. PMID 9111040.
  12. ^ Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076.
  13. ^ Zhou S, Hayward SD (Sep 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–32. doi:10.1128/mcb.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
  14. ^ Kurooka H, Honjo T (Jun 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–20. doi:10.1074/jbc.M000909200. PMID 10747963.
  15. ^ a b Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
  16. ^ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
  17. ^ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (Apr 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–10. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.