FBXO11

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FBXO11
Identifiers
Aliases FBXO11, FBX11, PRMT9, UBR6, VIT1, UG063H01, F-box protein 11
External IDs MGI: 2147134 HomoloGene: 11843 GeneCards: FBXO11
Genetically Related Diseases
schizophrenia[1]
RNA expression pattern
PBB GE FBXO11 203255 at fs.png

PBB GE FBXO11 222119 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001190274
NM_012167
NM_018693
NM_025133

NM_001081034
NM_001348248

RefSeq (protein)

NP_001177203
NP_079409

NP_001074503.1
NP_001074503

Location (UCSC) Chr 2: 47.79 – 47.91 Mb Chr 17: 87.99 – 88.07 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

F-box only protein 11 is a protein that in humans is encoded by the FBXO11 gene.[4][5][6][7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.[7]

References[edit]

  1. ^ "Diseases that are genetically associated with FBXO11 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  5. ^ Cook JR, Lee JH, Yang ZH, Krause CD, Herth N, Hoffmann R, Pestka S (Feb 2006). "FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues". Biochem Biophys Res Commun. 342 (2): 472–81. doi:10.1016/j.bbrc.2006.01.167. PMID 16487488. 
  6. ^ Lee MJ, Pal K, Tasaki T, Roy S, Jiang Y, An JY, Banerjee R, Kwon YT (Jan 2008). "Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway". Proc Natl Acad Sci U S A. 105 (1): 100–5. doi:10.1073/pnas.0708465105. PMC 2224166Freely accessible. PMID 18162545. 
  7. ^ a b "Entrez Gene: FBXO11 F-box protein 11". 

Further reading[edit]