FBXO5

FBXO5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M6N, 4UI9
Identifiers
Aliases	FBXO5, EMI1, FBX5, Fbxo31, F-box protein 5
External IDs	OMIM: 606013; MGI: 1914391; HomoloGene: 8135; GeneCards: FBXO5; OMA:FBXO5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q25.2 Start 152,970,519 bp End 152,983,579 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 A1 Start 5,749,160 bp End 5,755,600 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence secondary oocyte gonad bone marrow buccal mucosa cell cartilage tissue bone marrow cells trabecular bone testicle Top expressed in hand superior cervical ganglion maxillary prominence mandibular prominence primitive streak genital tubercle abdominal wall epiblast medial ganglionic eminence zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding protein kinase binding ubiquitin ligase inhibitor activity anaphase-promoting complex binding Cellular component cytoplasm cytosol spindle nucleoplasm cytoskeleton nucleus meiotic spindle Biological process vesicle organization regulation of meiotic nuclear division microtubule polymerization negative regulation of meiotic nuclear division regulation of transcription involved in G1/S transition of mitotic cell cycle cell division spindle assembly oocyte maturation regulation of mitotic cell cycle cell cycle spindle assembly involved in female meiosis I regulation of mitotic nuclear division negative regulation of ubiquitin protein ligase activity anaphase-promoting complex-dependent catabolic process negative regulation of mitotic metaphase/anaphase transition regulation of DNA replication positive regulation of cell population proliferation positive regulation of G2/M transition of mitotic cell cycle negative regulation of DNA endoreduplication positive regulation of osteoblast differentiation negative regulation of ubiquitin-protein transferase activity positive regulation of biomineral tissue development positive regulation of mesenchymal stem cell migration negative regulation of cellular senescence negative regulation of response to DNA damage stimulus protein ubiquitination regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26271 67141 Ensembl ENSG00000112029 ENSMUSG00000019773 UniProt Q9UKT4 Q7TSG3 RefSeq (mRNA) NM_001142522 NM_012177 NM_025995 RefSeq (protein) NP_001135994 NP_036309 NP_080271 Location (UCSC) Chr 6: 152.97 – 152.98 Mb Chr 10: 5.75 – 5.76 Mb PubMed search
Wikidata
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F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.

Interactions

FBXO5 has been shown to interact with:

• CDC20,
• FZR1, and
• SKP1A.

Further reading

• Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.
• Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet. Cell Genet. 88 (3–4): 255–8. doi:10.1159/000015532. PMID 10828603.
• Reimann JD, Freed E, Hsu JY, Kramer ER, Peters JM, Jackson PK (2001). "Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex". Cell. 105 (5): 645–55. doi:10.1016/S0092-8674(01)00361-0. PMID 11389834.
• Reimann JD, Jackson PK (2002). "Emi1 is required for cytostatic factor arrest in vertebrate eggs". Nature. 416 (6883): 850–4. doi:10.1038/416850a. PMID 11976684.
• Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738.
• Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng. 22 (4): 380–4. PMID 12703993.
• Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK (2003). "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase". Dev. Cell. 4 (6): 813–26. doi:10.1016/S1534-5807(03)00153-9. PMID 12791267.
• Moshe Y, Boulaire J, Pagano M, Hershko A (2004). "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome". Proc. Natl. Acad. Sci. U.S.A. 101 (21): 7937–42. doi:10.1073/pnas.0402442101. PMC 419535. PMID 15148369.
• Hansen DV, Loktev AV, Ban KH, Jackson PK (2005). "Plk1 Regulates Activation of the Anaphase Promoting Complex by Phosphorylating and Triggering SCFβTrCP-dependent Destruction of the APC Inhibitor Emi1". Mol. Biol. Cell. 15 (12): 5623–34. doi:10.1091/mbc.E04-07-0598. PMC 532041. PMID 15469984.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK (2006). "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1". Cell. 124 (2): 367–80. doi:10.1016/j.cell.2005.10.038. PMID 16439210.
• Lehman NL, Verschuren EW, Hsu JY, Cherry AM, Jackson PK (2006). "Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells". Cell Cycle. 5 (14): 1569–73. doi:10.4161/cc.5.14.2925. PMID 16861914.
• Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK (2006). "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor". Genes Dev. 20 (17): 2410–20. doi:10.1101/gad.1454006. PMC 1560415. PMID 16921029.
• Marangos P, Verschuren EW, Chen R, Jackson PK, Carroll J (2007). "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APCCdh1". J. Cell Biol. 176 (1): 65–75. doi:10.1083/jcb.200607070. PMC 2063628. PMID 17190794.