FBXW5

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FBXW5
Identifiers
Aliases FBXW5, Fbw5, F-box and WD repeat domain containing 5
External IDs MGI: 1354731 HomoloGene: 8496 GeneCards: FBXW5
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for FBXW5
Genomic location for FBXW5
Band 9q34.3 Start 136,940,435 bp[1]
End 136,944,696 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018998
NM_178225
NM_178226

NM_013908
NM_001356407
NM_001356408

RefSeq (protein)

NP_061871

NP_038936
NP_001343336
NP_001343337

Location (UCSC) Chr 9: 136.94 – 136.94 Mb Chr 2: 25.5 – 25.51 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.[5]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.[5]

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