SEC23B

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SEC23B
Identifiers
Aliases SEC23B, CDA-II, CDAII, CDAN2, HEMPAS, CWS7, Sec23 homolog B, coat complex II component
External IDs MGI: 1350925 HomoloGene: 74571 GeneCards: SEC23B
RNA expression pattern
PBB GE SEC23B 201582 at fs.png

PBB GE SEC23B 201583 s at fs.png

PBB GE SEC23B 210293 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032986
NM_001172745
NM_001172746
NM_006363
NM_032985

NM_001252543
NM_001252544
NM_001252545
NM_001281816
NM_019787

RefSeq (protein)

NP_001166216
NP_001166217
NP_006354
NP_116780
NP_116781

Location (UCSC) Chr 20: 18.51 – 18.56 Mb Chr 2: 144.56 – 144.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein transport protein Sec23B is a protein that in humans is encoded by the SEC23B gene.[3][4][5]

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration.

Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[5] Mutations in SEC23B cause an autosomal recessive disorder called congenital dyserythropoietic anemia type II (CDAII).

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Paccaud JP, Reith W, Carpentier JL, Ravazzola M, Amherdt M, Schekman R, Orci L (Mar 1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23". Mol Biol Cell. 7 (10): 1535–46. doi:10.1091/mbc.7.10.1535. PMC 276004Freely accessible. PMID 8898360. 
  4. ^ Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445. 
  5. ^ a b "Entrez Gene: SEC23B Sec23 homolog B (S. cerevisiae)". 

Further reading[edit]