FCER1A

From Wikipedia, the free encyclopedia
Jump to: navigation, search
FCER1A
Protein FCER1A PDB 1f2q.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FCER1A, FCE1A, FcERI, Fc fragment of IgE receptor Ia
External IDs MGI: 95494 HomoloGene: 1516 GeneCards: FCER1A
RNA expression pattern
PBB GE FCER1A 211734 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002001

NM_010184

RefSeq (protein)

NP_001992

NP_034314.2
NP_034314

Location (UCSC) Chr 1: 159.29 – 159.31 Mb Chr 1: 173.22 – 173.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene.[3]

Function[edit]

The high affinity IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes—potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha (this protein), beta, and gamma; only the alpha subunit is glycosylated.[4]

References[edit]

Further reading[edit]