MS4A2

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MS4A2
Identifiers
Aliases MS4A2, APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1, membrane spanning 4-domains A2
External IDs MGI: 95495 HomoloGene: 112 GeneCards: 2206
RNA expression pattern
PBB GE MS4A2 207496 at tn.png

PBB GE MS4A2 207497 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000139
NM_001142303
NM_001256916

NM_001276328
NM_001276329
NM_001276330
NM_013516

RefSeq (protein)

NP_000130.1

NP_038544.1

Location (UCSC) Chr 11: 60.09 – 60.1 Mb Chr 19: 11.62 – 11.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.[3][4]

Function[edit]

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Maekawa K, Imagawa N, Tanaka Y, Harada S (Aug 1992). "Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor". FEBS Lett. 302 (2): 161–5. doi:10.1016/0014-5793(92)80430-O. PMID 1386024. 
  4. ^ a b "Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.