Flavokavain B
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| Names | |
|---|---|
| IUPAC name
(E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-propenone
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| Other names
2'-hydroxy-4',6'-dimethoxychalcone
Flavokawain B | |
| Identifiers | |
3D model (JSmol)
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| 2059845 | |
PubChem CID
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| Properties | |
| C17H16O4 | |
| Molar mass | 284.311 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Flavokavain B is a flavokavain found in the kava plant.[1] In 2010 a paper was published identifying it as a hepatotoxin.[2] Flavokavain B has been demonstrated to possess potent apoptotic abilities.[3]
See also
References
- ^ Dharmaratne, H. Ranjith W. (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry. 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Zhou P., Gross S., Liu J.-H., Yu B.-Y., Feng L.-L., Nolta J., Sharma V., Piwnica-Worms D., Qiu S.X 'Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways . FASEB Journal 2010 24:12 (4722-4732)
- ^ Ramez N. Eskander1, Leslie M. Randall1, Toshinori Sakai, Yi Guy, Bang Hoang, Xiaolin Zi. "Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line".
{{cite web}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)