GPSM2

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GPSM2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GPSM2, CMCS, DFNB82, LGN, PINS, G-protein signaling modulator 2
External IDs MGI: 1923373 HomoloGene: 56584 GeneCards: GPSM2
RNA expression pattern
PBB GE GPSM2 205240 at fs.png

PBB GE GPSM2 221922 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013296
NM_001321038
NM_001321039

NM_029522

RefSeq (protein)

NP_083798.2
NP_083798

Location (UCSC) Chr 1: 108.88 – 108.93 Mb Chr 3: 108.68 – 108.72 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.[3][4][5]

Function[edit]

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM][5]

Interactions[edit]

GPSM2 has been shown to interact with Nuclear mitotic apparatus protein 1[6] and GNAI2.[4][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J. Biol. Chem. 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491. 
  4. ^ a b Mochizuki N, Cho G, Wen B, Insel PA (1996). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene. 181 (1-2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305. 
  5. ^ a b "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)". 
  6. ^ Du Q, Stukenberg PT, Macara IG (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568. 
  7. ^ Marty C, Browning DD, Ye RD (Jun 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206Freely accessible. PMID 12748287. 

Further reading[edit]