GSTP1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
GSTP1
Protein GSTP1 PDB 10gs.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases GSTP1, DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI, glutathione S-transferase pi 1
External IDs MGI: 3782108 HomoloGene: 660 GeneCards: 2950
RNA expression pattern
PBB GE GSTP1 200824 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000852

n/a

RefSeq (protein)

NP_000843.1

n/a

Location (UCSC) Chr 11: 67.58 – 67.59 Mb n/a
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene.[1][2]

Function[edit]

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.[3]

Interactions[edit]

GSTP1 has been shown to interact with Fanconi anemia, complementation group C[4][5] and MAPK8.[6]

GST-Pi is expressed in many human tissues, particularly in the biliary tree and renal distal convoluted tubules.[7]

Possible drug target[edit]

Triple-negative breast cancer cells rely on glutathione-S-transferase Pi1, and inhibitors are being studied.[8]

References[edit]

  1. ^ Bora PS, Bora NS, Wu XL, Lange LG (Oct 1991). "Molecular cloning, sequencing, and expression of human myocardial fatty acid ethyl ester synthase-III cDNA". J. Biol. Chem. 266 (25): 16774–7. PMID 1885604. 
  2. ^ Smith CM, Bora PS, Bora NS, Jones C, Gerhard DS (Nov 1995). "Genetic and radiation-reduced somatic cell hybrid sublocalization of the human GSTP1 gene". Cytogenet. Cell Genet. 71 (3): 235–9. doi:10.1159/000134117. PMID 7587384. 
  3. ^ "Entrez Gene: GSTP1 glutathione S-transferase pi". 
  4. ^ Cumming RC, Lightfoot J, Beard K, Youssoufian H, O'Brien PJ, Buchwald M (Jul 2001). "Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1". Nat. Med. 7 (7): 814–20. doi:10.1038/89937. PMID 11433346. 
  5. ^ Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (Oct 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622. 
  6. ^ Wang T, Arifoglu P, Ronai Z, Tew KD (Jun 2001). "Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus". J. Biol. Chem. 276 (24): 20999–1003. doi:10.1074/jbc.M101355200. PMID 11279197. 
  7. ^ Terrier, P; Townsend, AJ; Coindre, JM; Triche, TJ; Cowan, KH (October 1990). "An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue.". The American Journal of Pathology 137 (4): 845–53. PMID 1977319. 
  8. ^ Triple-negative breast cancer target is found. May 2016

Further reading[edit]

  • Strange RC, Fryer AA (1999). "The glutathione S-transferases: influence of polymorphism on cancer susceptibility". IARC Sci. Publ. (148): 231–49. PMID 10493261. 
  • Kellen E, Hemelt M, Broberg K, Golka K, Kristensen VN, Hung RJ, Matullo G, Mittal RD, Porru S, Povey A, Schulz WA, Shen J, Buntinx F, Zeegers MP, Taioli E (2007). "Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review". Am. J. Epidemiol. 165 (11): 1221–30. doi:10.1093/aje/kwm003. PMID 17404387. 
  • Sekine I, Minna JD, Nishio K, Tamura T, Saijo N (2006). "A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer". J Thorac Oncol 1 (1): 31–7. doi:10.1097/01243894-200601000-00008. PMID 17409824.